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Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice
Jr., A. S. Aguiar; Moreira, E. L. G.; Hoeller, A. A.; Oliveira, P. A.; Córdova, F. M.; Glaser, V.; Walz, R.; Cunha, R. A.; Leal, R. B.; Latini, A.l-DOPA alleviates the motor symptoms of Parkinson’s disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this l-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with l-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercis...
Cross-cultural translation of the INSPIRIT-R for Brazil and its applicability a...
Veronez,I S; Bicalho,M A H; Claudino,L S; Walz,R; Lin,KOBJECTIVE: To describe the cross-cultural adaptation of the INSPIRIT-R instrument for evaluation of religious and spiritual experiences into a Brazilian Portuguese version and its applicability among epileptic patients. METHOD: After the translation and back-translation phases, a multidisciplinary committee compared the back-translation with the original text in order to evaluate its content, comprehensibility,...
Serum and cerebrospinal fluid S100B concentrations in patients with neurocystic...
Lima,J.E.; Walz,R.; Tort,A.; Souza,D.; Portela,L.; Bianchin,M.M.; Takayanagui,O.M.; Leite,J.P.The clinical manifestations of neurocysticercosis (NC) are varied and depend on the number and location of cysts, as well as on the host immune response. Symptoms usually occur in NC when cysticerci enter a degenerative course associated with an inflammatory response. The expression of brain damage markers may be expected to increase during this phase. S100B is a calcium-binding protein produced and released pr...
Differential role of entorhinal and hippocampal nerve growth factor in short- a...
Walz,R.; Roesler,R.; Reinke,A.; Martins,M.R.; Quevedo,J.; Izquierdo,I.We studied the effects of infusion of nerve growth factor (NGF) into the hippocampus and entorhinal cortex of male Wistar rats (250-300 g, N = 11-13 per group) on inhibitory avoidance retention. In order to evaluate the modulation of entorhinal and hippocampal NGF in short- and long-term memory, animals were implanted with cannulae in the CA1 area of the dorsal hippocampus or entorhinal cortex and trained in on...
Infusions of AP5 into the basolateral amygdala impair the formation, but not th...
Roesler,R.; Vianna,M.R.M.; de-Paris,F.; Quevedo,J.; Walz,R.; Bianchin,M.We evaluated the effects of infusions of the NMDA receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (AP5) into the basolateral nucleus of the amygdala (BLA) on the formation and expression of memory for inhibitory avoidance. Adult male Wistar rats (215-300 g) were implanted under thionembutal anesthesia (30 mg/kg, ip) with 9.0-mm guide cannulae aimed 1.0 mm above the BLA. Bilateral infusions of AP5 (5.0...
Agents that affect cAMP levels or protein kinase A activity modulate memory con...
Bevilaqua,L.; Ardenghi,P.; Schröder,N.; Bromberg,E.; Quevedo,J.; Schmitz,P.K.; Bianchin,M.; Walz,R.; Schaeffer,E.; Medina,J.H.; Izquierdo,I.Male Wistar rats were trained in one-trial step-down inhibitory avoidance using a 0.4-mA footshock. At various times after training (0, 1.5, 3, 6 and 9 h for the animals implanted into the CA1 region of the hippocampus; 0 and 3 h for those implanted into the amygdala), these animals received microinfusions of SKF38393 (7.5 µg/side), SCH23390 (0.5 µg/side), norepinephrine (0.3 µg/side), timolol (0.3 µg/side), 8-...
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