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Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice
Jr., A. S. Aguiar; Moreira, E. L. G.; Hoeller, A. A.; Oliveira, P. A.; Córdova, F. M.; Glaser, V.; Walz, R.; Cunha, R. A.; Leal, R. B.; Latini, A.l-DOPA alleviates the motor symptoms of Parkinson’s disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this l-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with l-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercis...
Spatial memory impairments in a prediabetic rat model
Soares, E.; Prediger, R. D.; Nunes, S.; Castro, A. A.; Viana, S .D.; Lemos, C.; Souza, C. M. De; Agostinho, P.; Cunha, R. A.; Carvalho, E.Diabetes is associated with an increased risk for brain disorders, namely cognitive impairments associated with hippocampal dysfunction underlying diabetic encephalopathy. However, the impact of a prediabetic state on cognitive function is unknown. Therefore, we now investigated whether spatial learning and memory deficits and the underlying hippocampal dysfunction were already present in a prediabetic animal m...
Anandamide and NADA bi-directionally modulate presynaptic Ca<sup>2+</sup> level...
Köfalvi, A.; Pereira, M. F.; Rebola, N.; Rodrigues, R. J.; Oliveira, C. R.; Cunha, R. A.Inhibitory CB1 cannabinoid receptors and excitatory TRPV1 vanilloid receptors are abundant in the hippocampus. We tested if two known hybrid endocannabinoid/endovanilloid substances, N-arachidonoyl-dopamine (NADA) and anandamide (AEA), presynapticaly increased or decreased intracellular calcium level ([Ca2+]i) and GABA and glutamate release in the hippocampus. Resting and K+-evoked levels of [Ca2+]i and the rel...
Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized...
Tebano, M. T.; Martire, A.; Rebola, N.; Pepponi, R.; Domenici, M. R.; Grò, M. C.; Schwarzschild, M. A.; Chen, J. F.; Cunha, R. A.; Popoli, P.Hippocampal metabotropic glutamate 5 receptors (mGlu5Rs) regulate both physiological and pathological responses to glutamate. Because mGlu5R activation enhances NMDA-mediated effects, and given the role played by NMDA receptors in synaptic plasticity and excitotoxicity, modulating mGlu5R may influence both the physiological and the pathological effects elicited by NMDA receptor stimulation. We evaluated whether...
Recovery of hippocampal metabolism from hypoxia - role of the adenosine A1 rece...
Duarte, J. M.; Cunha, R. A.; Carvalho, R. A.Título do suplemento: Book of Abstracts ESMRMB 2005 22nd Annual Scientific Meeting Basle/CH, Sept. 15-18, 2005
Purinergic P2 receptors trigger adenosine release leading to adenosine A2A rece...
Almeida, T.; Rodrigues, R. J.; Mendonça, A. de; Ribeiro, J. A.; Cunha, R. A.Electrophysiological recordings were used to investigate the effects of ATP analogues on [theta]-burst-induced long-term potentiation (LTP) in rat hippocampal slices. [alpha],[beta]-Methylene ATP ([alpha],[beta]-MeATP; 20 [mu]M) decreased LTP from 36±9% to 17±5%, an effect prevented by adenosine A1 receptor blockade in accordance with the localised catabolism of ATP analogues into adenosine, leading to adenosin...
Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dep...
Lopes, L. V.; Cunha, R. A.; Kull, B.; Fredholm, B. B.; Ribeiro, J. A.Adenosine tonically inhibits synaptic transmission through actions at A1 receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre- and/or postsynaptic A2A receptor activation or from indirect control of inhibitory GABAergic transmission. The A2A receptor agonist, CGS 21680 (10 nM), facilitated synaptic transmission in the CA1 area of rat hippocampal slices (b...
Regulation of the Ecto-Nucleotidase Pathway in Rat Hippocampal Nerve Terminals
Cunha, R.A.Ecto-nucleotidases play a pivotal role in terminating the signalling via ATP and in producing adenosine, a neuromodulator in the nervous system. We have now investigated the pattern of adenosine formation with different concentrations of extracellular ATP in rat hippocampal nerve terminals. It was found that adenosine formation is delayed with increasing concentrations of ATP. Also, the rate of adenosine format...
Regulation of the Ecto-Nucleotidase Pathway in Rat Hippocampal Nerve Terminals
Cunha, R. A.Ecto-nucleotidases play a pivotal role in terminating the signalling via ATP and in producing adenosine, a neuromodulator in the nervous system. We have now investigated the pattern of adenosine formation with different concentrations of extracellular ATP in rat hippocampal nerve terminals. It was found that adenosine formation is delayed with increasing concentrations of ATP. Also, the rate of adenosine format...
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