Microscale flow dynamics of red blood cells in a circular microchannel

• Author(s): Lima, R. ; Nakamura, M. ; Ishikawa, Takuji ; Tanaka, S. ; Takeda, Motohiro ; Imai, Yohsuke ; Tsubota, Ken-ichi ; Wada, Shigeo ; Yamaguchi, Takami
• Date: 2008
• Persistent ID: http://hdl.handle.net/10198/4981
• Origin: Biblioteca Digital do IPB
• Subject(s): Blood flow; Microcirculation
• Document Type: Article
• Language: English

Description

The blood flow dynamics in microcirculation depends strongly on the motion, deformation and interaction of RBCs within the microvessel. This paper presents the application of a confocal micro-PTV system to track RBCs through a circular polydimethysiloxane (PDMS) microchannel. This technique, consists of a spinning disk confocal microscope, high speed camera and a diode-pumped solid state (DPSS) laser combined with a single particle tracking (SPT) method. By using this system detailed motions of individual RBCs were measured at a microscale level. Our results showed that this technique can provide detailed information about microscale disturbance effects caused by RBCs in flowing blood.