Encontrados 22 documentos, a visualizar página 1 de 3
Microscale flow dynamics of red blood cells in microchannels: an experimental a...
Lima, R.; Nakamura, M.; Omori, T.; Ishikawa, Takuji; Wada, Shigeo; Yamaguchi, TakamiApproximately, the half volume of the blood is composed of red blood cells (RBCs) which is believed to strongly influence its flow properties. Blood flow in microvessels depends strongly on the motion, deformation and interaction of RBCs. Several experimental studies on both individual and concentrated RBCs have already been performed in the past (Goldsmith 1971, Goldsmith and Marlow 1979, Chien et al. 1984, Go...
Measurement of individual red blood cell motions under high hematocrit conditio...
Lima, R.; Ishikawa, Takuji; Imai, Yohsuke; Takeda, Motohiro; Wada, Shigeo; Yamaguchi, TakamiDevelopments in optical experimental techniques have helped in elucidating how blood flows through microvessels. Although initial developments were encouraging, studies on the flow properties of blood in microcirculation have been limited by several technical factors, such as poor spatial resolution and difficulty obtaining quantitative detailed measurements at such small scales. Recent advances in computing, m...
In vitro blood flow in a rectangular PDMS microchannel: experimental observatio...
Lima, R.; Wada, Shigeo; Tanaka, S.; Takeda, Motohiro; Ishikawa, Takuji; Tsubota, Ken-ichi; Imai, Yohsuke; Yamaguchi, TakamiProgress in microfabricated technologies has attracted the attention of researchers in several areas, including microcirculation. Microfluidic devices are expected to provide powerful tools not only to better understand the biophysical behavior of blood flow in microvessels, but also for disease diagnosis. Such microfluidic devices for biomedical applications must be compatible with state-of-the-art flow measur...
Radial dispersion of red blood cells in blood flowing through glass capillaries...
Lima, R.; Ishikawa, Takuji; Imai, Yohsuke; Takeda, Motohiro; Wada, Shigeo; Yamaguchi, TakamiThe flow properties of blood in the microcirculation depend strongly on the hematocrit (Hct), microvessel geometry, and cell properties. Previous in vitro studies have measured the radial displacement of red blood cells (RBCs) at concentrated suspensions using conventional microscopes. However, to measure the RBCs motion they used transparent suspensions of ghost red cells, which may have different physical pro...
Dispersion of red blood cells in microchannels : a confocal micro-PTV assessment
Lima, R.; Ishikawa, Takuji; Imai, Yohsuke; Fujiwara, Hiroki; Takeda, Motohiro; Matsuki, Noriaki; Wada, Shigeo; Yamaguchi, TakamiBlood in large arteries may be treated as a homogenous fluid from a macroscopic prospective. However, in reality blood is a suspension of deformable cells in viscous fluid plasma. In microcirculation, which comprises the smallest arteries and veins, the flow behavior of individual blood cells and their interactions provide the microrheological basis of flow properties of blood at a macroscopic level. Hence, in ...
The role of the hematocrit on the radial dispersion of red blood cells in glass...
Lima, R.; Ishikawa, Takuji; Imai, Yohsuke; Takeda, Motohiro; Wada, Shigeo; Yamaguchi, TakamiThe flow properties of blood in the microcirculation depend strongly on the hematocrit (Hct), microvessel geometry, and cell properties. Previous in vitro studies have measured the radial displacement of red blood cells (RBCs) at concentrated suspensions using conventional microscopes. However, they have used transparent suspensions of ghost red cells, which may have different physical properties than normal RB...
Determination of blood cells motions and interactions by a confocal micro-PIV s...
Lima, R.; Ishikawa, Takuji; Imai, Yohsuke; Takeda, Motohiro; Wada, Shigeo; Yamaguchi, TakamiThe development of optical experimental techniques has contributed to obtain explanations on the way the blood flows through microvessels. Although the past results have been encouraging, detailed studies on the flow properties of blood in the microcirculation has been limited by several technical factors such as poor spatial resolution and difficulty to obtain quantitative detailed measurements at such small s...
Microscale flow dynamics of red blood cells in a circular microchannel
Lima, R.; Nakamura, M.; Ishikawa, Takuji; Tanaka, S.; Takeda, Motohiro; Imai, Yohsuke; Tsubota, Ken-ichi; Wada, Shigeo; Yamaguchi, TakamiThe blood flow dynamics in microcirculation depends strongly on the motion, deformation and interaction of RBCs within the microvessel. This paper presents the application of a confocal micro-PTV system to track RBCs through a circular polydimethysiloxane (PDMS) microchannel. This technique, consists of a spinning disk confocal microscope, high speed camera and a diode-pumped solid state (DPSS) laser combined w...
Measurement of multi-red blood cells interactions in blood flow by confocal mic...
Lima, R.; Ishikawa, Takuji; Fujiwara, Hiroki; Takeda, Motohiro; Imai, Yohsuke; Tsubota, Ken-ichi; Matsuki, Noriaki; Wada, Shigeo; Yamaguchi, TakamiIn microcirculation the flow behavior of red blood cells (RBCs) plays a crucial role in many physiological and pathological phenomena. For instance, the interaction of RBCs in shear flow is believed to play an important role to the thrombogenesis process. Despite the relevance of this phenomenon on the blood mass transport, very little studies have been performed during the years, partly due to the absence of a...
In vitro confocal micro-PIV measurements of blood flow in a square microchannel:...
Lima, R.; Wada, Shigeo; Takeda, Motohiro; Tsubota, Ken-ichi; Yamaguchi, TakamiA confocal microparticle image velocimetry (micro-PIV) system was used to obtain detailed information on the velocity profiles for the flow of pure water (PW) and in vitro blood (haematocrit up to 17%) in a 100-μm-square microchannel. All the measurements were made in the middle plane of the microchannel at a constant flow rate and low Reynolds number (Re=0.025). The averaged ensemble velocity profiles were fou...
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