Microscale flow dynamics of red blood cells in microchannels: an experimental a...

• Author(s): Lima, R. ; Fernandes, Carla S. ; Dias, Ricardo P. ; Ishikawa, T. ; Imai, Y. ; Yamaguchi, T.
• Date: 2011
• Persistent ID: http://hdl.handle.net/10198/10314
• Origin: Biblioteca Digital do IPB
• Subject(s): Blood flow; Bifurcation; Microchannel; Microvascular networks
• Document Type: Part of book or chapter of book
• Language: English

Description

The blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxane (PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system, we have measured the effect of bifurcation on the flow behaviour of both fluorescent particles diluted in pure water and RBCs in concentrated suspensions. After performing simulations with the commercial finite element software package POLYFLOW, some experimental results were compared with the numerical results and the limitations of these simulations were outlined.