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Human red blood cell behavior under homogeneous extensional flow in a hyperboli...
Yaginuma, Tomoko; Oliveira, M. S. N.; Lima, R.; Ishikawa, T.; Yamaguchi, T.It is well known that certain pathological conditions result in a decrease of red blood cells (RBCs) deformability and subsequently can significantly alter the blood flow in microcirculation, which may block capillaries and cause ischemia in the tissues. Microfluidic systems able to obtain reliable quantitative measurements of RBC deformability hold the key to understand and diagnose RBC related diseases. In th...
Confocal micro-PIV/PTV measurements of the blood flow in micro-channels
Lima, R.; Ishikawa, T.; Imai, Y.; Yamaguchi, T.The development of optical experimental techniques has contributed to obtain explanations on the blood flow behaviour through micro-channels. Although the past results have been valuable, detailed studies on the flow properties of in vitro blood in micro-channels have been limited by several technical factors such as poor spatial resolution and difficulty to obtain quantitative detailed meas-urements at such sm...
Flow of red blood cells through a microfluidic extensional device : an image an...
Yaginuma, T.; Pereira, Ana I.; Rodrigues, P. J.; Lima, R.; Oliveira, M.S. N.; Ishikawa, T.; Yamaguchi, T.The present study aims to assess the deformability of red blood cells (RBCs) under extensionally dominated microfluidic flows using an image based technique. For this purpose, a microchannel having a hyperbolic shaped-contraction was used and the images were captured by a standard high-speed microscopy system. The images acquired display RBCs with various light intensity levels and image analysis was used to qu...
Microscale flow dynamics of red blood cells in microchannels: an experimental a...
Lima, R.; Fernandes, Carla S.; Dias, Ricardo P.; Ishikawa, T.; Imai, Y.; Yamaguchi, T.The blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxane (PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system, we have measured the effect of bi...
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