A few detailed studies have been performed in complex in vitro microvascular networks composed by bifurcations and confluences. The main purpose of the present work is to numerically simulate the flow of two distinct fluids through bifurcation and confluence geometries, i. e red blood cells (RBCs) suspended in Dextran40 with about 14% of heamatocrit and pure water. The simulations of pure water and RBCs flows w...
A few detailed studies have been performed in complex in vitro microvascular networks composed by bifurcations and confluences. The main purpose of the present work is to numerically simulate the flow of two distinct fluids through bifurcation and confluence geometries, i. e red blood cells (RBCs)suspended in Dextran40 with about 14% of heamatocrit and pure water. The simulations of pure water and RBCs flows we...
Several experimental techniques were performed in the past years using in vitro environments, in an attempt to not only understand the blood flow behaviour in microcirculation but also develop microfluidic devices as an alternative clinical methodology to detect blood diseases. Hence, the visualization and measurement of red blood cells (RBCs) flowing in a microfluidic device are important to provide not only e...
In this chapter we discuss the cell-free layer (CFL) developed adjacent to the wall of microgeometries containing complex features representative of the microcirculation, such as contractions, expansions, bifurcations and confluences. The microchannels with the different geometries were made of polydimethylsiloxane (PDMS) and we use optical techniques to evaluate the cell-free layer for red blood cells (RBC) su...
O artigo deve também estar associado ao Departamento de Electrotécnia, Tecnologia Mecânica e Química ; In the present work, in vitro blood flowing through a bifurcation microchannel was studied. The aim was to measure the Trajectories of the cell-free layer (CFL) by using different methods, i. e., a manual and two automatic methods.
Human blood is a multiphase biofluid primarily composed by the deformable red blood cells (RBCs) suspended in plasma. Because the complex structure of RBCs, blood exhibits unique flow characteristics on micro-scale level, due to their complex biochemical mechanisms and their response to both shear and extensional flow, which influence the rheological properties and flow behaviour of blood [1,2]. In the past yea...
O sucesso de todos os procedimentos envolventes nas manutenções preventivas depende de decisões, uma boa gestão prévia e organização de todos os órgãos envolventes, para que os equipamentos médicos maximizem o seu desempenho e prolonguem a sua vida útil a um custo compensador para a instituição hospitalar. Dentro deste contexto, foram elaboradas listagens exaustivas aos equipamentos à medida que se executavam a...
O sangue é um fluido fisiológico de elevada importância para o normal funcionamento do organismo humano pois desempenha funções essenciais à vida. Um ser humano possui cerca de 5 litros de volume sanguíneo no organismo onde, aproximadamente, metade desse volume é composto por eritrócitos e estes influenciam fortemente as propriedades do escoamento sanguíneo. A microcirculação tem uma função muito importante na ...
Blood exhibits unique flow characteristics on micro-scale level, due to the complex biochemical structure of Red Blood Cells (RBCs) and their response to both shear and extensional flow, which influence the rheological properties and flow behavior of blood [1,2]. In the past years, several in vitro studies where made and have revealed some physiologically significant phenomena, such as Fahraeus and Fahraeus-Lin...
Blood exhibits unique flow characteristics on micro-scale level, due to the complex biochemical structure of Red Blood Cells (RBCs) and their response to both shear and extensional flow, which influence the rheological properties and flow behavior of blood [1,2]. In the past years, several in vitro studies where made and have revealed some physiologically significant phenomena, such as Fahraeus and Fahraeus-Lin...
Financiadores do RCAAP | |||||||
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |