Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associa...

• Autor(es): Barreto, M. ; Ferreira, RC. ; Lourenço, L. ; Moraes-Fontes, MF. ; Santos, E. ; Alves, M. ; Carvalho, C. ; Martins, B. ; Andreia, R. ; Viana, JF. ; Vasconcelos, C. ; Mota-Vieira, L. ; Ferreira, C. ; Demengeot, J. ; Vicente, AM.
• Data: 2007
• Identificador Persistente: http://hdl.handle.net/10400.7/160
• Origem: ARCA - Access to Research and Communication Annals
• Assunto(s): REGULATORY T-CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; IMMUNOLOGICAL SELF-TOLERANCE; IN-VIVO EXPANSION; AUTOANTIBODY PRODUCTION; MULTIPLE-SCLEROSIS
• Tipo de Documento: Artigo

Descrição

Background: CD4(+)CD25(+) regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease characterized by loss of tolerance to nuclear components and significantly more frequent in females.