Autor(es):
Schmitt, Fernando C. 
; Longatto Filho, Adhemar ; Valent, Alexander ; Vielh, Philippe
Data: 2008
Identificador Persistente: http://hdl.handle.net/1822/7899
Origem: RepositóriUM - Universidade do Minho
Assunto(s): Cytopathology; Molecular biology; FISH; FNA
Descrição
The last decade was stimulating with the introduction of new molecular techniques to be applied in pathology laboratories. Accordingly, cytology was also benefited with the innovations emerged from this new era. Molecular cytopathology (MCP) can be defined as molecular studies applied on all types of cytological specimens, namely gynaecology cytology, exfoliative non-gyn
cytology and fine needle aspirates. The development of a huge amount of new
ancillary techniques has paralleled the emergence of clinical cytology as a major diagnostic speciality. Clinical applications of these techniques have been growing in the last decade. The widespread acceptance of liquid-based systems in gynaecological cytology is a paramount episode which re-draws the relation between cells and molecules. The stretched use of approaches, morphology and molecular biology, in HPV-induced lesions settings, e.g., revealed a
potential to optimize, in one single brushed sample, diagnosis and research.
Cytology samples from serous effusions, pulmonary tree, bladder urine, and aspirations, among others, are now likely to be studied by different molecular
techniques for helping in diagnosis, prognosis, or even to assess therapeutic
targets. In this review, we highlight the main results already published concerning the application of molecular techniques in different fields of cytopathology and discuss their application.
