The relevance of the brain in the diseased heart : authors' response

• Author(s): Palha, Joana Almeida ; Cerqueira, Jo??o ; Sousa, Nuno ; Pereira, Vitor H.
• Date: 2013
• Persistent ID: http://hdl.handle.net/1822/29728
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Cardiovascular diseases; Circadian rhythm; Melatonin; Cortisol
• Document Type: Article
• Language: English

Description

The relevance of the brain in the diseased heart: Authors' response In their comment to our recent paper entitled ???Stressed Brain, Diseases Heart: A review on the pathophysiologic mechanisms of neurocardiology.??? [1], Dominguez-Rodriguez and Abreu-Gonzalez [2] emphasize the relevance of circadian rhythm in cardiovascular diseases and propose the suprachiasmatic nucleus and melatonin as key mediators in its pathophysiology. We found this a very interesting observation. The incidence of acute myocardial infarction [3] and its extension [4] displays a circadian pattern usually peaking in early morning.