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Stressed brain, diseased heart : a review on the pathophysiologic mechanisms of...
Pereira, Vitor H.; Cerqueira, João; Palha, Joana Almeida; Sousa, NunoCardiovascular diseases are traditionally related to well known risk factors like dyslipidemia, smoking, diabetes and hypertension. More recently, stress, anxiety and depression have been proposed as risk factors for cardiovascular diseases including heart failure, ischemic disease, hypertension and arrhythmias. Interestingly, this association has been established largely on the basis of epidemiological data, d...
The relevance of the brain in the diseased heart : authors' response
Palha, Joana Almeida; Cerqueira, Jo??o; Sousa, Nuno; Pereira, Vitor H.The relevance of the brain in the diseased heart: Authors' response ; In their comment to our recent paper entitled ???Stressed Brain, Diseases Heart: A review on the pathophysiologic mechanisms of neurocardiology.??? [1], Dominguez-Rodriguez and Abreu-Gonzalez [2] emphasize the relevance of circadian rhythm in cardiovascular diseases and propose the suprachiasmatic nucleus and melatonin as key mediators in it...
Biodistribution and preliminary therapeutic potential of CMCht/PAMAM dendrimer ...
Cerqueira, Susana R.; Pereira, Vitor H.; Oliveira, Joaquim M.; Sousa, Nuno; Salgado, A. J.; Reis, R. L.The development of drug delivery systems (DDS) for targeted intracellular delivery of therapeutic agents has been attracting great deal of attention. In traumatic central nervous system conditions, where therapies have been revealing to be highly inneficient and non-specific, these targeted DDS could be highly beneficial. We have previously shown in vitro studies where the carboxymethylchitosan (CMCht)/ poly(am...
In vivo biodistribution of carboxymethylchitosan/poly(amidoamine) dendrimer nan...
Pereira, Vitor H.; Salgado, A. J.; Oliveira, Joaquim M.; Cerqueira, Susana R.; Frias, A. M.; Fraga, J. S.; Roque, Susana; Falcão, Ana M.Carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles (CMCht/PAMAM) have recently been proposed for intracellular drug delivery purposes. These are constituted by a PAMAM dendrimer core grafted with chains of CMCht. Previous reports have shown that these nanoparticles disclosed an improved cytotoxic profile when compared to traditional dendrimers. Following on these results the present study aims to as...
Carboxymethylchitosan/poly (amidoamine) dendrimer nanoparticles in central nerv...
Salgado, A. J.; Oliveira, Joaquim M.; Pirraco, Rogério; Pereira, Vitor H.; Fraga, J. S.; Marques, A. P.; Neves, N. M.; Mano, J. F.; Reis, R. L.The applicability of CMCht/PAMAM dendrimer nanoparticles for CNS applications was investigated. AFM and TEM observations revealed that the nanoparticles possessed a nanosphere- like shape with a size from 22.0 to 30.7 nm. The nanoparticles could be bound to fluorescent-probe FITC for tracing purposes. Post-natal hippocampal neurons and cortical glial cells were both able to internalize the FITC-labeled CMCht/PA...
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