Encontrados 36 documentos, a visualizar página 1 de 4
Clinical, physical and lifestyle variables and relationship with cognition and ...
Santos, Nadine Correia; Costa, Patr??cio Soares; Cunha, Pedro Miguel Guimar??es Marques da; Nunes, Carlos Portugal; Amorim, Liliana; Cotter, JorgeIt is relevant to unravel the factors that may mediate the cognitive decline observed during aging. Previous reports indicate that education has a positive influence on cognitive performance, while age, female gender and, especially, depressed mood were associated with poorer performances across multiple cognitive dimensions (memory and general executive function). Herein, the present study aimed to characteriz...
Telephone-based screening tools for mild cognitive impairment and dementia in a...
Castanho, Teresa C.; Amorim, Liliana; Zihl, Joseph; Palha, Joana Almeida; Sousa, Nuno; Santos, Nadine CorreiaThe decline of cognitive function in old age is a great challenge for modern society. The simultaneous increase in dementia and other neurodegenerative diseases justifies a growing need for accurate and valid cognitive assessment instruments. Although in-person testing is considered the most effective and preferred administration mode of assessment, it can pose not only a research difficulty in reaching large a...
Stressed brain, diseased heart : a review on the pathophysiologic mechanisms of...
Pereira, Vitor H.; Cerqueira, João; Palha, Joana Almeida; Sousa, NunoCardiovascular diseases are traditionally related to well known risk factors like dyslipidemia, smoking, diabetes and hypertension. More recently, stress, anxiety and depression have been proposed as risk factors for cardiovascular diseases including heart failure, ischemic disease, hypertension and arrhythmias. Interestingly, this association has been established largely on the basis of epidemiological data, d...
Lipocalin-2 is involved in emotional behaviors and cognitive function
Ferreira, Ana Catarina; Pinto, Vítor; Mesquita, Sandro; Novais, Ashley da Cruz; Sousa, João Carlos; Neves, Margarida Correia; Sousa, NunoLipocalin-2 is involved in emotional behaviors and cognitive function ; Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display a...
Stress impact on resting state brain networks
Soares, José Miguel; Sampaio, Adriana; Ferreira, Luís Miguel; Santos, Nadine Correia; Marques, Fernanda; Palha, Joana Almeida; Cerqueira, JoãoResting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect ...
The use of Bayesian latent class cluster models to classify patterns of cogniti...
Costa, Patrício Soares; Santos, Nadine Correia; Cunha, Pedro; Palha, Joana Almeida; Sousa, NunoThe main focus of this study is to illustrate the applicability of latent class analysis in the assessment of cognitive performance profiles during ageing. Principal component analysis (PCA) was used to detect main cognitive dimensions (based on the neurocognitive test variables) and Bayesian latent class analysis (LCA) models (without constraints) were used to explore patterns of cognitive performance among co...
Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons...
João, Bessa; Morais, Mónica; Marques, Fernanda; Pinto, Luísa; Palha, Joana Almeida; Sousa, NunoThere is accumulating evidence that the nucleus accumbens (NAc) has an important role in the pathophysiology of depression. As the NAc is a key component in the neural circuitry of reward, it has been hypothesized that anhedonia, a core symptom of depression, might be related to dysfunction of this brain region. Neuronal morphology and expression of plasticity-related molecules were examined in the NAc of rats ...
Plasticity of resting state brain networks in recovery from stress
Marques, Fernanda; Palha, Joana Almeida; Cerqueira, Jo??o; Soares, Jos?? Miguel; Sousa, Nuno; Santos, Nadine Correia; Marques, Paulo C??sar Gon??alvesChronic stress has been widely reported to have deleterious impact in multiple biological systems. Specifically, structural and functional remodeling of several brain regions following prolonged stress exposure have been described; importantly, some of these changes are eventually reversible. Recently, we showed the impact of stress on resting state networks (RSNs), but nothing is known about the plasticity of ...
The relevance of the brain in the diseased heart : authors' response
Palha, Joana Almeida; Cerqueira, Jo??o; Sousa, Nuno; Pereira, Vitor H.The relevance of the brain in the diseased heart: Authors' response ; In their comment to our recent paper entitled ???Stressed Brain, Diseases Heart: A review on the pathophysiologic mechanisms of neurocardiology.??? [1], Dominguez-Rodriguez and Abreu-Gonzalez [2] emphasize the relevance of circadian rhythm in cardiovascular diseases and propose the suprachiasmatic nucleus and melatonin as key mediators in it...
Blood-brain-barriers in aging and in Alzheimer's disease
Marques, Fernanda; Sousa, João Carlos; Sousa, Nuno; Palha, Joana AlmeidaThe aging process correlates with a progressive failure in the normal cellular and organ functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and AD there is a general decrease in the capacity of the body to eliminate toxic compounds and, simultaneously, to supply the brain with relevant growth and nutritional factors. The barriers of the brain are targets of this age related...
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