Detalhes do Documento

Development and characterization of PHB-HV based 3D scaffolds for a tissue engi...

Autor(es): Samy, S. M. cv logo 1 ; Silva, Nuno cv logo 2 ; Pinto, Luísa cv logo 3 ; Castro, Andreia Cristiana Teixeira de cv logo 4 ; Almeida, Hugo Leite cv logo 5 ; Almeida, Armando cv logo 6 ; Sousa, Nuno cv logo 7 ; Salgado, António J. cv logo 8 ; Gimble, Jeffrey M. cv logo 9 ; Reis, R. L. cv logo 10

Data: 2013

Identificador Persistente: http://hdl.handle.net/1822/25184

Origem: RepositóriUM - Universidade do Minho


Descrição
Spinal cord injury (SCI) leads to devastating neurological deficits. Several tissue engineering (TE)- based approaches have been investigated for repairing this condition. Poly (3-hydroxybutyrateco- 3-hydroxyvalerate) (PHB-HV) is found to be particularly attractive for TE applications due to its properties, such as biodegradability, biocompatibility, thermoplasticity and piezoelectricity. Hence, this report addresses the development and characterization of PHB-HV-based 3D scaffolds, produced by freeze-drying, aimed to SCI treatment. The obtained scaffolds reveal an anisotropic morphology with a fully interconnected network of pores. In vitro studies demonstrate a lack of cytotoxic effect of PHB-HV scaffolds. Direct contact assays also reveal their ability to support the culture of CNS-derived cells and mesenchymal-like stem cells from different sources. Finally, histocompatibility studies show that PHB-HV scaffolds are well tolerated by the host tissue, and do not negatively impact the left hindlimb locomotor function recovery. Therefore results herein presented suggest that PHB-HV scaffolds may be suitable for SCI treatment.
Tipo de Documento Artigo
Idioma Inglês
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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia