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Development and characterization of PHB-HV based 3D scaffolds for a tissue engi...
Samy, S. M.; Silva, Nuno; Pinto, Luísa; Castro, Andreia Cristiana Teixeira de; Almeida, Hugo Leite; Almeida, Armando; Sousa, Nuno; Salgado, António J.Spinal cord injury (SCI) leads to devastating neurological deficits. Several tissue engineering (TE)- based approaches have been investigated for repairing this condition. Poly (3-hydroxybutyrateco- 3-hydroxyvalerate) (PHB-HV) is found to be particularly attractive for TE applications due to its properties, such as biodegradability, biocompatibility, thermoplasticity and piezoelectricity. Hence, this report add...
Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disea...
Carvalho, Miguel; Campos, Filipa L.; Coimbra, Bárbara Guimarães Salazar; Pêgo, José M.; Lima, Rui; Rodrigues, Ana João; Sousa, Nuno; Salgado, António J.BACKGROUND: Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence of non-motor symptoms in PD patients, as a consequence of damage on the mesolimbic and mesocortical dopaminergic netwo...
Role of kainate receptor activation and desensitization on the [Ca2+]i changes ...
Silva, Ana P.; Malva, João O.; Ambrósio, António F.; Salgado, António J.; Carvalho, Arsélio P.; Carvalho, Caetana M.We investigated the role of kainate (KA) receptor activation and desensitization in inducing the increase in the intracellular free Ca2+ concentration ([Ca2+]i) in individual cultured rat hippocampal neurons. The rat hippocampal neurons in the cultures were shown to express kainate receptor subunits, KA2 and GluR6/7, either by immunocytochemistry or by immunoblot analysis. The effect of LY303070, an alpha-amino...
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