Chitosan membranes containing micro or nano-size bioactive glass particles : ev...

• Author(s): Caridade, S. G. ; Merino, Esther G. ; Alves, N. M. ; Zea Bermudez, V. de ; Boccaccini, A. R. ; Mano, J. F.
• Date: 2013
• Persistent ID: http://hdl.handle.net/1822/23719
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Bioactive glass; Bioactivity; Bone regeneration.; Dynamic mechanical analysis; Nanocomposites
• Document Type: Article
• Language: English

Description

A newfamilyofbiodegradablepolymer/bioactiveglass(BG)compositematerialshas emergedbasedontheavailabilityofnano-sizedbioactiveparticles.Suchnovelbiocompo- sites canhaveenhancedperformance,intermsofmechanicalpropertiesandbioactivity, and theycanbedesignedtobeusedinboneregenerationapproaches. In thiswork,membranesofchitosan(CTS)andchitosanwithbioactiveglass(BG)both micron andnanosizedparticles(CTS/mBG,CTS/nBG,respectively)werepreparedby solvent casting.Microstructuralandmechanicalpropertieswereevaluatedinorderto compare theeffectsoftheincorporationofmicro(mBG) andnano(nBG)particlesinthe chitosan matrix. In vitro bioactivity testswereperformedtocharacterizetheapatitelayer that isformedonthesurfaceofthematerialafterbeingimmersedinsimulatedbodyfluid (SBF). Thebiomineralizationprocessonthebiomaterialswasalsofollowedusingnon- conventionaldynamicmechanicalanalysis(DMA),bothonlineandoffline.InsuchDMA experiments,thechangeinthestoragemodulus, E0, andthelossfactor,tan d, were measured asafunctionoftheimmersiontimeinSBF.TheresultsdemonstratedthatCTS/ nBG membranespossessenhancedmechanicalpropertiesandhigherbioactivityin comparisonwiththeCTS/mBG membranes.SuchresultssuggestthepotentialofnBGfor the developmentofbioactivecompositesforboneregenerationapplications.