Encontrados 36 documentos, a visualizar página 1 de 4
Bioactive macro/micro porous silk fibroin/Nano-sized calcium phosphate scaffold...
Yan, Leping; Correia, Joana Silva; Correia, C.; Caridade, S. G.; Fernandes, E. M.; Sousa, R. A.; Mano, J. F.; Oliveira, Joaquim M.; Oliveira, A. L.Aim: The development of novel silk/nano-sized calcium phosphate (silk/nano-CaP) scaffolds with highly dispersed CaP nanoparticles in the silk fibroin (SF) matrix for bone tissue engineering. Materials & methods: Nano-CaP was incorporated in a concentrated aqueous SF solution (16 wt.%) by using an in situ synthesis method. The silk/nano-CaP scaffolds were then prepared through a combination of salt-leaching/ lyo...
Hybrid biodegradable membranes of silane-treated chitosan/soy protein for biome...
Silva, S. S.; Oliveira, Joaquim M.; Benesch, Johan; Caridade, S. G.; Mano, J. F.; Reis, R. L.In recent years, progress in the field of hybrid materials has been accelerated through use of the sol–gel process for creating materials and devices, which benefit from the incorporation of both inorganic and organic components. In this work, organic–inorganic hybrid membranes were prepared from tetraethoxysilane and a blend system composed of chitosan and soy protein. By introducing a small amount of siloxane...
Revealing the potential of squid chitosan-based structures for biomedical appli...
Reys, L. L.; Silva, S. S.; Oliveira, Joaquim M.; Caridade, S. G.; Mano, J. F.; Silva, Tiago H.; Reis, R. L.In recent years, much attention has been given to different marine organisms, namely as potential sources of valuable materials with a vast range of properties and characteristics. In this work, β-chitin was isolated from the endoskeleton of the giant squid Dosidicus gigas and further deacetylated to produce chitosan. Then, the squid chitosan was processed into membranes and scaffolds using solvent casting and ...
Chondrogenic potential of injectable K-carrageenan hydrogel with encapsulated a...
Popa, Elena G.; Caridade, S. G.; Mano, J. F.; Reis, R. L.; Gomes, Manuela E.Due to the limited self-repair capacity of cartilage, regenerative medicine therapies for the treatment of cartilage defects must use a significant amount of cells, preferably applied using a hydrogel system that can promise their delivery and functionality at the specific site. This paper discusses the potential use of k-carrageenan hydrogels for the delivery of stem cells obtained from adipose tissue in the t...
Asymmetric PDLLA membranes containing Bioglass® for guided tissue regeneration ...
Leal, Ana Isabel; Caridade, S. G.; Ma, J.; Yu, N.; Gomes, Manuela E.; Reis, R. L.; Jansen, John A.; Walboomers, X. F.; Mano, J. F.Objective. In the treatment of periodontal defects, composite membranes might be applied to protect the injured area and simultaneously stimulate tissue regeneration. This work describes the development and characterization of poly(d,l-lactic acid)/Bioglass® (PDLLA/BG) composite membranes with asymmetric bioactivity. We hypothesized that the presence of BG microparticles could enhance structural and osteoconduc...
An investigation of the potential application of chitosan/aloe-based membranes ...
Silva, S. S.; Popa, Elena G.; Gomes, Manuela E.; Cerqueira, M. T.; Marques, A. P.; Caridade, S. G.; Teixeira, P.; Sousa, Cláudia; Mano, J. F.A significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation beh...
Chitosan membranes containing micro or nano-size bioactive glass particles : ev...
Caridade, S. G.; Merino, Esther G.; Alves, N. M.; Zea Bermudez, V. de; Boccaccini, A. R.; Mano, J. F.A newfamilyofbiodegradablepolymer/bioactiveglass(BG)compositematerialshas emergedbasedontheavailabilityofnano-sizedbioactiveparticles.Suchnovelbiocompo- sites canhaveenhancedperformance,intermsofmechanicalpropertiesandbioactivity, and theycanbedesignedtobeusedinboneregenerationapproaches. In thiswork,membranesofchitosan(CTS)andchitosanwithbioactiveglass(BG)both micron andnanosizedparticles(CTS/mBG,CTS/nBG,respe...
Silk-Fibroin/Methacrylated Gellan Gum Hydrogel as an novel scaffold for applica...
Pereira, H.; Correia, Joana Silva; Yan, Leping; Caridade, S. G.; Frias, A. M.; Oliveira, A. L.; Mano, J. F.; Oliveira, Joaquim M.Introduction: Knee meniscus injury is highly prevalent and there is a demand for new cost-effective treatment solutions. Tissue engineering (TE) and regenerative medicine strategies using acellular scaffolds are being used in clinical application for total or partial meniscus replacement [1]. Although this strategy has been considered as a safe and promising approach, progressive volume reduction of the implant...
Biomineralization in chitosan/Bioglass® composite membranes under different dyn...
Caridade, S. G.; Merino, Esther G.; Alves, N. M.; Mano, J. F.Fundamental aspects of biomineralization may be important in order to understand and improve calcification onto the surface of biomaterials. The biomineralization process is mainly followed in vitro by assessing the evolution of the apatite layer that is formed upon immersion of the material in Simulated Body Fluid (SBF). In this work we propose an innovative methodology to monitor apatite deposition by looking...
Effect of crosslinking in chitosan/aloe vera-based membranes for biomedical app...
Silva, S. S.; Caridade, S. G.; Mano, J. F.; Reis, R. L.The positive interaction between polysaccharides with active phytochemicals found in medicinal plants may represent a strategy to create active wound dressing materials useful for skin repair. In the present work, blended membranes composed of chitosan (Cht) and Aloe vera gel were prepared through the solvent casting, and were crosslinked with genipin to improve their prop...
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