Development of a bilayered scaffold based on silk fibroin and silk fibroin/nano...

• Author(s): Yan, Leping ; Oliveira, Joaquim M. ; Oliveira, A. L. ; Reis, R. L.
• Date: 2012
• Persistent ID: http://hdl.handle.net/1822/23148
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Bilayered scaffolds; Silk fibroin
• Document Type: Conference Object
• Language: English

Description

Objectives: Osteochondral defect is a common condtion in clinic. Satisfactory outcomes are rarely achieved by traditional methods. Tissue engineering might be a promising strategy for this hinder. The aim of this study is to mimick the stratified structure of osteochondral tissue, by developing a bilayered scaffold for osteochondral regeneration. The developed bilayered scaffold is composed of a porous silk fibroin scaffold as the cartilage-like layer and a porous silk fibroin/nano-calcium phosphate (CaP) scaffold as the bone-like layer.