Bonelike/PLGA hybrid materials for bone regeneration : in vivo evaluation

• Author(s): Oliveira, Joaquim M. ; Lopes, M. A. ; Kawai, T. ; Ohtsuki, C. ; Santos, J. D. ; Afonso, A.
• Date: 2004
• Persistent ID: http://hdl.handle.net/1822/17472
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Bonelike; Histological studies; Hybrid materials; In vivo; PLGA
• Document Type: Article
• Language: English

Description

The biocompatibility and osteoconductive potential of Bonelike and Bonelike /PLGA hybrid materials were evaluated through subcutaneous and tibiae implantations for a 4 week period. Qualitative histology was performed to evaluate new bone formation and characterise bone-implant interface and results showed that Bonelike /PLGA hybrid materials promote extensive bone growth. After the 4 week implantation period, Bonelike resorption was recognized, which may be due to the presence of resorbable and -tricalcium phosphate phases.