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Bonelike/PLGA hybrid materials for bone regeneration : preparation route and ph...
Oliveira, Joaquim M.; Miyazaki, T.; Lopes, M. A.; Ohtsuki, C.; Santos, J. D.Bonelike R /PLGA hybrid materials have been developed using γ -MPS as silane-coupling agent between the inorganic and organic phases for controlled drug delivery applications. Silanization showed to be more effective when cyclohexane was used as a non-polar solvent (nP method) due to a chemical interaction between Bonelike R and the silane film, while by using a 95/5 (V/V) methanol/water as a polar solvent (P m...
Bonelike/PLGA hybrid materials for bone regeneration : in vivo evaluation
Oliveira, Joaquim M.; Lopes, M. A.; Kawai, T.; Ohtsuki, C.; Santos, J. D.; Afonso, A.The biocompatibility and osteoconductive potential of Bonelike and Bonelike /PLGA hybrid materials were evaluated through subcutaneous and tibiae implantations for a 4 week period. Qualitative histology was performed to evaluate new bone formation and characterise bone-implant interface and results showed that Bonelike /PLGA hybrid materials promote extensive bone growth. After the 4 week implantation period, ...
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