Synthesis of new tacrine analogues from 4-Aminopyrrole-3-carbonitrile

• Author(s): Salaheldin, Abdellatif M. ; Campos, Ana M. F. Oliveira ; Parpot, Pier ; Rodrigues, Lígia M. ; Oliveira, M. Manuel ; Peixoto, Francisco
• Date: 2010
• Persistent ID: http://hdl.handle.net/1822/10646
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Tacrine; Friedländer reaction; Alzheimer disease; Acetylcholinesterase; Thorpe-Ziegler cyclization; Microwave irradiation
• Document Type: Article
• Language: English

Description

An easy preparation of 4-aminopyrrole-3-carbonitrile derivatives, and their transformation into new substituted pyrrolo[3,2-b]pyridines is described, in one step, via Friedländer reaction under microwave irradiation and classical heating methods. The use of microwave irradiation led to high conversion and shorter times.