Este estudo teve como principal objetivo realizar uma análise diferencial do autoconceito artístico entre adolescentes que frequentavam o ensino artístico e os que frenquentavam o ensino regular. Responderam à Escala de Autoconceito Artístico e à Escala de Autoconceito e Autoestima para Adolescentes 226 estudantes de escolas da zona metropolitana de Lisboa, dos quais 108 frequentavam o ensino regular e 118 eram...
AIM: Ketamine can induce hepatotoxicity which has been suggested to be dependent on mitochondrial impairment. This study investigated the long-term effects of chronic low-dose ketamine on liver mitochondrial function, oxidative stress parameters, liver histology and glycogen content. MAIN METHODS: Adult rats were administered with saline or ketamine (5 or 10mg/kg) twice a day for a fourteen-day period in orde...
Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats were fed for 11, 22 and 33 days with a rapeseed oil-based diet and mitochondrial bioenergetics, a...
The increasing use of C60 nanoparticles and the diversity of their applications in industry and medicine has led to their production in a large scale. C60 release into wastewaters and the possible accumulation in the environment has raised concerns about their ecotoxicological impact. In the present study, an aqueous suspension of C60 nanoparticles was prepared and its potential toxicity studied in laboratory, ...
Berberine is an isoquinoline alkaloid with anti-diabetic properties. Despite the central role of liver and thus hepaticmitochondria inwhole-bodymetabolism, berberine effects on hepaticmitochondrial function in an obesity model are still unknown. Here, we demonstrate that berberine treatment recovers mitochondrial efficiency when altered by a high-fat feeding.Mitochondria isolated from the liver of high-fat fed ...
O presente estudo teve por objetivo o estudo das características psicométricas da Escala de Valores de Schwartz, no sentido de confirmar a sua adequação numa amostra de professores portugueses. Esta escala é uma versão reduzida do Portrait Values Scale (PVS) desenvolvido por Schwartz et al. (2001). É constituída por 21 itens, que refletem 10 valores motivacionais em quatro orientações fundamentais, organizadas ...
Barbel (Barbus bocagei) a common species in Portuguese rivers was studied to assess the impact of water contamination on hepatic oxidative stress response, lipid peroxidation and histology. The Vizela River is a tributary of the Ave River, located in one of the most industrialized areas of Portugal. The oxidative stress biomarkers analyzed included superoxide dismutase, catalase, glutathione S-transferase, glut...
Chaetomellic acid A (CA) is a potent and highly specific inhibitor of Ras farnesyl-protein transferase that has shown to decrease oxidative stress in rats with brain damage. Oxidative stress has been suggested to play an important role in the pathogenesis of chronic renal disease. Thus, the aim of this work was to evaluate the effect of chronic treatment with CA on oxidative stress in a model of renal mass redu...
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