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Lipidomic approach of the biological activity of tacrine and two tacrine-analog...

Tacrine and its analogues impair mitochondrial function and bioenergetics : a l...

Tacrine is an acetylcholinesterase inhibitor used as cognitive enhancer in Alzheimer's disease treatment. However, the low therapeutic efficiency and the high incidence of side effects have limited its clinical use. In the present study, the molecular mechanisms underlying the brain activity of tacrine and two novel tacrine analogues (T1, T2) were approached focusing on three aspects: i) effects on brain cholin...

Synthesis of new tacrine analogues from 4-Aminopyrrole-3-carbonitrile

An easy preparation of 4-aminopyrrole-3-carbonitrile derivatives, and their transformation into new substituted pyrrolo[3,2-b]pyridines is described, in one step, via Friedländer reaction under microwave irradiation and classical heating methods. The use of microwave irradiation led to high conversion and shorter times.

Cleavages of photochromic compounds derived from heterocycles under electrospra...

In this paper we report the fragmentation pathways of chromenes derived from carbazole, dibenzofuran and dibenzothiophene, under ESI-MS/MS experimental conditions, and their relationship with structural features, specially focused on the heteroatom’s effect on the fragmentation mechanisms.

Studies under Continuous Irradiation of Photochromic Spiro[fluorenopyran-thioxa...

New indeno-fused spiro[benzopyran-thioxanthenes] were synthesized (see 3a-d in Scheme 3) and their photochromic properties evaluated under continuous irradiation (Table 1). When submitted to irradiation for several minutes with a Xe lamp, the system behaved as one constituted by two open colored forms with different thermal bleaching rates and different susceptibilities to degradation. An increase in irradiatio...

Electrospray tandem mass spectrometry of 2H-chromenes

Several 2H-chromenes, derived from carbazoles, were analyzed by electrospray tandem mass spectrometry. The 2H-chromenes constitute an important class of compounds that exhibit photochromic activity. The fragmentation pathways of the protonated molecular species [M+H]+ were studied and main fragmentation pathways of these compounds were identified. Fragmentation pathways of [M+D]+ ions were also studied in orde...