Blockade of adenosine A2A receptors prevents protein phosphorylation in the str...

• Author(s): Quiroz, César ; Gomes, Catarina ; Pak, Arlene C. ; Ribeiro, Joaquim A. ; Goldberg, Steven R. ; Hope, Bruce T. ; Ferré, Sergi
• Date: 2006
• Persistent ID: http://hdl.handle.net/10451/8188
• Origin: Repositório da Universidade de Lisboa
• Subject(s): Caffeine; Adenosine A2A receptor; Striatum; Phosphorylation; ERK1/2; AMPA receptor
• Document Type: Article
• Language: English

Description

©2006 Society for Neuroscience Previous studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons. In the present study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A receptor antagonist counteracts the striatal activation of cAMP– protein kinase A cascade (phosphorylation of the Ser845 residue of the glutamate receptor 1 subunit of the AMPA receptor) and mitogenactivated protein kinase (ERK1/2 phosphorylation) induced by the in vivo stimulation of corticostriatal afferents. The results indicate that A2A receptors strongly modulate the efficacy of glutamatergic synapses on striatal enkephalinergic neurons.