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Caffeine and adenosine
Ribeiro, Joaquim A.; Sebastião, Ana M.© 2010 – IOS Press and the authors. All rights reserved ; Caffeine causes most of its biological effects via antagonizing all types of adenosine receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons and glial cells of all brain areas. In consequence, caffeine, when acting as an AR antagonist, is doing the opposite of activation of adenosine receptors due to removal of endogeno...
Activation of adenosine A2A receptors induces TrkB translocation and increases ...
Assaife-Lopes, Natália; Sousa, Vasco C.; Pereira, Daniela B.; Ribeiro, Joaquim A.; Chao, Moses V.; Sebastião, Ana M.Copyright © 2010 the authors ; Brain-derived neurotrophic factor (BDNF) signaling is critical for neuronal development and transmission. Recruitment of TrkB receptors to lipid rafts has been hown to be necessary for the activation of specific signaling pathways and modulation of neurotransmitter release by BDNF. Since TrkB receptors are known to be modulated by adenosine A2A receptor activation, we hypothesize...
Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity dur...
Fontinha, Bruno M; Delgado-García, José M; Madroñal, Noelia; Ribeiro, Joaquim A; Sebastião, Ana M; Gruart, Agnès© 2009 Nature Publishing Group All rights reserved ; Previous in vitro studies have characterized the electrophysiological and molecular signaling pathways of adenosine tonic modulation on long-lasting synaptic plasticity events, particularly for hippocampal long-term potentiation(LTP). However, it remains to be elucidated whether the long-term changes produced by endogenous adenosine in the efficie...
Blockade of adenosine A2A receptors prevents protein phosphorylation in the str...
Quiroz, César; Gomes, Catarina; Pak, Arlene C.; Ribeiro, Joaquim A.; Goldberg, Steven R.; Hope, Bruce T.; Ferré, Sergi©2006 Society for Neuroscience ; Previous studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons. In the present study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A receptor antagonist counteracts the striata...
Adenosine A3 receptors in the rat hippocampus: Lack of interaction with A1 rece...
Lopes, Luísa V.; Rebola, Nelson; Costenla, Ana Rita; Halldner, Linda; Jacobson, Marlene A.; Oliveira, Catarina R.; Richardson, Peter J.Adenosine acts as a neuromodulator in the hippocampus essentially through activation of inhibitory A1 receptors. Using single-cell PCR analysis, we found that CA1 pyramidal cells coexpress A1 receptor mRNA together with that of another adenosine receptor, the A3 receptor. As occurs for the A1 receptor, Western blot analysis indicated that the A3 receptor is also located in hippocampal nerve terminals. However, ...
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