New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synt...

• Autor(es): Teixeira, Fátima C. ; Lucas, Carla ; Curto, Maria João Marcelo ; Neves, M. ; Duarte, M. Teresa ; André, Vânia ; Teixeira, A. P. S.
• Data: 2013
• Identificador Persistente: http://hdl.handle.net/10400.9/2033
• Origem: Repositório do LNEG
• Assunto(s): Bisphosphonates; Spectroscopic characterization; Synthesis; X-ray diffractometry
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono- and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the proposed structure.