Formaldehyde's genotoxicity effects in pathology anatomy technologists and medi...

• Author(s): Ladeira, Carina ; Viegas, Susana ; Prista, J. ; Gomes, Manuel C. ; Brito, Miguel
• Date: 2011
• Persistent ID: http://hdl.handle.net/10400.21/652
• Origin: Repositório Científico do Instituto Politécnico de Lisboa
• Subject(s): Anatomia patológica; Saúde ocupacional; Meio laboratorial; Formaldeído; Biomarcador tumoral
• Document Type: Conference Object
• Language: English

Description

Formaldehyde (FA) had been considered to be carcinogenic by the International Agency for Research on Cancer (group1), on the basis of sufficient evidence both in humans and in experimental animals, making it a subject of major environmental concern, especially in the occupational context. Manifold in vitro studies clearly indicated that FA is genotoxic, inducing various genotoxic effects in proliferating cultured mammalian cells. Cytokinesis-blocked micronucleus (CBMN) assay is used extensively in molecular epidemiology, and the chromosomal alterations most reported and studied by the CBMN are: micronucleus (MN), nucleoplasmic bridges (NPB) and nuclear buds (NBUDs). The pathology anatomy laboratories are work places that manipulate routinely FA and pathology anatomy technologists and pathologists contact daily with this chemical compound particularly in the macroscopic exam and grossing procedures. The aim of this study was to identify genotoxicity biomarkers in the set workers groups, such as micronucleus (MN), nucleoplasmic bridges (NPB) and nuclear buds (NBUD) in peripheral blood lymphocytes.