SbCl5—wet acetonitrile: a new system for chemoselective O-desilylation

• Autor(es): Glória, Paulo M. C. ; Prabhakar, Sundaresan ; Lobo, Ana M. ; Gomes, Mário
• Data: 2003
• Identificador Persistente: http://hdl.handle.net/10400.21/1003
• Origem: Repositório Científico do Instituto Politécnico de Lisboa
• Assunto(s): Química; TBDMS
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

Abstract—A new efficient method for deprotection of TBDMS derivatives of phenols, primary alcohols, carboxylic acids and secondary amines, consisting of SbCl5 and MeCN with 0.1% water (w/v), is reported. It effects inter alia desilylation of a CH2OTBDMS group in the presence of a ketal function.