Lymphocyte ceruloplasmin and Behçet's disease

• Author(s): Oliveira, R. ; Banha, J. ; Martins, F. ; Paixão, E. ; Pereira, D. ; Barcelos, F. ; Teixeira, A. ; Patto, J.V. ; Costa, L.
• Date: 2006
• Persistent ID: http://hdl.handle.net/10400.18/326
• Origin: Repositório Científico do Instituto Nacional de Saúde
• Subject(s): Behçet’s disease; Ceruloplasmin; Prooxidant/antioxidant Balance; Lymphocytes; Azathioprine; Determinantes Imunológicos em Doenças Crónicas
• Document Type: Article
• Language: Portuguese

Description

Behçet's disease (BD) is a rare chronic inflammatory disorder of unknown aetiology. However, it has been postulated that a dysregulation of the prooxidant/antioxidant balance may be important to its pathogenesis. Ceruloplasmin (CP) is an acute phase protein expressed at the surface of peripheral blood lymphocytes (PBL) with antioxidant properties and with a relevant role in iron (Fe) metabolism.