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Inflammatory stimuli modulates the expression of ceruloplasmin at surface of hu...
Bispo, C.; Villares, A.; Banha, J.; Marques, L.; Costa, L.Atherosclerosis (ATH) is recognized as a chronic inflammatory condition and it is the leading cause of cardiovascular disease. Atherogenesis is characterized by the passage of LDL through the endothelial layer, and the early infiltration and activation of peripheral blood lymphocytes (PBL) and monocytes (PBMN) that contribute to a pro-inflammatory state in specific locations. However, the functional interaction...
Differential Regulation of Ceruloplasmin Isoforms Expression in Macrophages and...
Marques, L.; Auriac, A.; Willemetz, A.; Banha, J.; Silva, B.; Canonne-Hergaux, F.; Costa, L.Prémio de melhor poster. ; Ceruloplasmin (Cp) is an acute-phase protein that has been implicated in iron metabolism due to its ferroxidase activity, assisting ferroportin (Fpn) on cellular iron efflux. However, Cp exhibits both anti- and pro-oxidant activities and its physiological functions remain unclear. Cp can be expressed as a secreted or as a membrane glycosylphosphatidylinositol-anchored protein (GPI-Cp...
Lymphocyte ceruloplasmin and Behçet's disease
Oliveira, R.; Banha, J.; Martins, F.; Paixão, E.; Pereira, D.; Barcelos, F.; Teixeira, A.; Patto, J.V.; Costa, L.Behçet's disease (BD) is a rare chronic inflammatory disorder of unknown aetiology. However, it has been postulated that a dysregulation of the prooxidant/antioxidant balance may be important to its pathogenesis. Ceruloplasmin (CP) is an acute phase protein expressed at the surface of peripheral blood lymphocytes (PBL) with antioxidant properties and with a relevant role in iron (Fe) metabolism.
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