Efavirenz concentrations in HIV-infected patients with and without viral hepatitis

• Author(s): Pereira, S ; Caixas, U ; Branco, T ; Germano, I ; Lampreia, F ; Papoila, A ; Monteiro, E
• Date: 2008
• Persistent ID: http://hdl.handle.net/10400.10/672
• Origin: Repositório do Hospital Prof. Doutor Fernando Fonseca
• Subject(s): Infecção por HIV; Hepatite B; Hepatite C; HIV infections; Hepatitis B; Hepatitis C; Efavirenz
• Document Type: Article
• Language: English

Description

AIMS: Data on efavirenz in HIV/viral hepatitis co-infected patients is non-consensual, probably due to liver function heterogeneity in the patients included. METHODS: A case control study was performed on 27 HIV-infected patients, with controlled and homogenous markers of hepatic function, either mono-infected or co-infected with HBV/HCV, to ascertain the influence of viral hepatitis on efavirenz concentrations over a 2-year follow-up period. RESULTS: No differences were found in efavirenz concentrations between groups both during and at the end of the follow-up period: control (2.43 +/- 1.91 mg l(-1)) vs. co-infected individuals (2.37 +/- 0.37 mg l(-1)). CONCLUSION: It was concluded that HBV/HCV infections in themselves do not predispose to an overexposure to efavirenz.