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HIV-2 Integrase Polymorphisms and Longitudinal Genotypic Analysis of HIV-2 Infe...

Cavaco-Silva, J; Abecasis, A; Miranda, AC; Poças, J; Narciso, J; Águas, MJ; Maltez, F; Almeida, I; Germano, I; Diniz, A; Gonçalves, MF; Gomes, P

To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase r...


Dosimetric Study of Enhanced Dynamic Wedges to Clinical Implementation into XiO...

C. Rodrigues; V. Batel; S. Germano; I. Monteiro Grillo; J.L. Pinto

This work presents the physical and dosimetric properties of the Enhanced Dynamic Wedges (EDW) including depth doses, beam profiles and effective wedge attenuatin factors (EWAF) by experimental determinations.The measurements were performed for 6 MV at a Linear accelerator Varian Clinac 2100 C/D, Varian Medical Systems. The main purpose of this work was to study the dosimetric properties of EDW in order to impl...

Data: 2012   |   Origem: Electrónica e Telecomunicações

Linfoma Primário das Cavidades em Doente com Infecção VIH

Gouveia, S; Castro, M; Correia, R; Germano, I; Farrajota, F

O linfoma primário das cavidades é um subtipo de linfoma não-Hodgkin (LNH), de ocorrência rara, prognóstico muito reservado, mais frequentemente descrito em indivíduos imunodeprimidos, em particular no contexto de infecção pelo vírus da imunodeficiência humana (VIH), no qual as células malignas proliferam exclusivamente nas cavidades serosas e que está associado ao vírus herpes humano tipo 8 (VHH8). Os autores ...


Long-Term Maraviroc Use As Salvage Therapy in HIV-2 Infection

Caixas, U; Ferreira, J; Marinho, A; Faustino, I; Grilo, N; Lampreia, F; Germano, I; Monteiro, E; Pereira, S


Effect of efavirenz on high-density lipoprotein antioxidant properties in HIV-i...

Pereira, S; Batuca, J; Caixas, U; Branco, T; Delgado-Alves, J; Germano, I; Lampreia, F; Monteiro, E

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * In previous work, we showed a long-term and concentration-dependent beneficial effect of the non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) on high-density lipoproteins (HDL) in human immunodeficiency virus (HIV)-infected patients. * Furthermore, it has been suggested that instead of the current practice of only measuring HDL-chelesterol values, the ev...


Effect of Efavirenz on High-Density Lipoprotein Antioxidant Properties in HIV-I...

Pereira, SA; Batuca, JR; Caixas, U; Branco, T; Delgado-Alves, J; Germano, I; Lampreia, F; Monteiro, EC

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * In previous work, we showed a long-term and concentration-dependent beneficial effect of the non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) on high-density lipoproteins (HDL) in human immunodeficiency virus (HIV)-infected patients. * Furthermore, it has been suggested that instead of the current practice of only measuring HDL-chelesterol values, the ev...


Efavirenz concentrations in HIV-infected patients with and without viral hepatitis

Pereira, S; Caixas, U; Branco, T; Germano, I; Lampreia, F; Papoila, A; Monteiro, E

AIMS: Data on efavirenz in HIV/viral hepatitis co-infected patients is non-consensual, probably due to liver function heterogeneity in the patients included. METHODS: A case control study was performed on 27 HIV-infected patients, with controlled and homogenous markers of hepatic function, either mono-infected or co-infected with HBV/HCV, to ascertain the influence of viral hepatitis on efavirenz concentration...


Efavirenz Concentrations in HIV-Infected Patients With and Without Viral Hepatitis

Pereira, SA; Caixas, U; Branco, T; Germano, I; Lampreia, F; Papoila, AL; Monteiro, E

AIMS: Data on efavirenz in HIV/viral hepatitis co-infected patients is non-consensual, probably due to liver function heterogeneity in the patients included. METHODS: A case control study was performed on 27 HIV-infected patients, with controlled and homogenous markers of hepatic function, either mono-infected or co-infected with HBV/HCV, to ascertain the influence of viral hepatitis on efavirenz concentration...


Long-Term and Concentration-Dependent Beneficial Effect of Efavirenz on HDL-Cho...

Pereira, SA; Branco, T; Côrte-Real, R; Germano, I; Lampreia, F; Caixas, U; Monteiro, E

AIMS: To investigate the long-term effects of efavirenz on cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL-C) and triglycerides (TG). METHODS: Thirty-four HIV-infected patients who commenced efavirenz therapy were monitored for 36 months. RESULTS: In patients with baseline HDL-C<40 mg.dL-1 an increase in HDL-C from 31+/-1 mg.dL-1 to 44+/-2 mg.dL-1 (95% confidence i...


Hematomas Cerebelosos em Doente com Mixoma Auricular

Marcão, I; Teixeira, H; Germano, I; Bandeira Costa, J; Gonçalves, C; Magalhães, M; Farrajota, F

Apresenta-se um caso clínico de mixoma auricular, numa mulher de 69 anos, que teve como manifestação inaugural síndroma cerebeloso, causado por enfartes isquémicos da circulação posterior. O Ecocardiograma transtorácico bidimensional permitiu formular o diagnóstico de mixoma da aurícula esquerda. Ao 7° mês pós remoção cirúrgica do tumor cardíaco houve agravamento do síndroma cerebeloso e instalação de quadro de...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia