Comparison of the voltammetric behavior of metronidazole at a DNA-modified glas...

• Autor(es): Brett, Ana Maria Oliveira ; Serrano, Silvia H. P. ; Gutz, Ivano G. R. ; La-Scalea, Mauro A.
• Data: 1997
• Identificador Persistente: http://hdl.handle.net/10316/8302
• Origem: Estudo Geral - Universidade de Coimbra
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

The electroanalytical performance at three electrodes: DNA-modified galssy carbon electrode, mercury thin film electrode and glassy carbon electrode, for the study of the electrochemical reduction of metronidazole is compared. All three electrodes showed a similar trend in the reduction mechanism for metronidazole, depenent on pH in the acid and neutral region and independent in alkaline media, although there was a shift in the peak potentials to more negative values when a bare glassy carbon electrode was used compared to the other two. Besides the advantage of using a solid electrode for the reduction of metronidazole, the DNA-modified galssy carbon electrode enables a lower detection limit of 1.0 muM owing to the preconecentration of the drug on the electrode surface, which is not the case for the mercury thin film or bare glassy carbon electrodes. http://dx.doi.org/10.1002/elan.1140090204