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Eletrodos modificados com DNA: uma nova alternativa em eletroanálise
La-Scalea,Mauro A.; Serrano,Silvia H. P.; Gutz,Ivano G. R.The first studies about DNA electrochemistry appeared at the end of the fifties. The voltammetric techniques became important tool for the DNA conformational analysis, producing evidences about DNA double helix polimorphism. The new techniques based on electrodes modification with nucleic acid enlarged the use of the electrochemical methods on the DNA research. DNA electrochemical biosensors are able to detect ...
Voltammetric Behaviour of Metronidazole at Mercury Electrodes
La-Scalea,Mauro A.; Serrano,Silvia H.P.; Gutz,Ivano G.R.Metronidazole is the most important drug of the group of 5-nitroimidazoles and possesses toxicity to anaerobic micro-organisms DNA being the main target for their biological action. The mechanism of biological action of metronidazole is dependent upon the nitro group reduction process. The reduction of metronidazole is pH dependent in acid medium and four electrons are involved in the complete reduction to the ...
Comparison of the voltammetric behavior of metronidazole at a DNA-modified glas...
Brett, Ana Maria Oliveira; Serrano, Silvia H. P.; Gutz, Ivano G. R.; La-Scalea, Mauro A.The electroanalytical performance at three electrodes: DNA-modified galssy carbon electrode, mercury thin film electrode and glassy carbon electrode, for the study of the electrochemical reduction of metronidazole is compared. All three electrodes showed a similar trend in the reduction mechanism for metronidazole, depenent on pH in the acid and neutral region and independent in alkaline media, although there w...
Electrochemical determination of carboplatin in serum using a DNA-modified glas...
Brett, Ana Maria Oliveira; Serrano, Sílvia H. P.; Macedo, Tice A.; Raimundo, Dulce; Marques, M. Helena; La-Scalea, Mauro A.An electrochemical method for the determination of the anticancer platinum drug carboplatin using a DNA-modified electrode was developed. This electrode was successfully used for the electrochemical determination of carboplatin in serum samples of patients with ovarian cancer undergoing treatment. The electrochemical results clearly demonstrated that, for low concentrations, carboplatin interacts preferentially...
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