Autor(es):
Moreira, João N. 
; Ishida, Tatsuhiro ; Gaspar, Rogério ; Allen, Theresa M.
Data: 2002
Identificador Persistente: http://hdl.handle.net/10316/7964
Origem: Estudo Geral - Universidade de Coimbra
Detalhes do Documento
Use of the Post-Insertion Technique to Insert Peptide Ligands into Pre-Formed S...
Descrição
Purpose: Simple methods for the large-scale manufacture of ligand-targeted liposomes will be needed if clinical trials are to proceed. We tested a recently developed technology for inserting peptide ligands into preformed Stealth liposomes. Antagonist G-targeted liposomes (PLG) were prepared and loaded with doxorubicin and their cellular association and cytotoxicity were evaluated using the human small cell lung cancer H69 cell line. http://dx.doi.org/10.1023/A:1014434732752
Purpose: Simple methods for the large-scale manufacture of ligand-targeted liposomes will be needed if clinical trials are to proceed. We tested a recently developed technology for inserting peptide ligands into preformed Stealth liposomes. Antagonist G-targeted liposomes (PLG) were prepared and loaded with doxorubicin and their cellular association and cytotoxicity were evaluated using the human small cell lung cancer H69 cell line. http://dx.doi.org/10.1023/A:1014434732752
Tipo de Documento
Artigo
Idioma Inglês
Idioma Inglês
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