Background: In healthy subjects, inspiratory muscle activation may reduce peripheral blood flow, a response know as the inspiratory muscle-mediated metaboreflex. Objectives: We tested the hypothesis that inspiratory muscle activation during recovery of intense exercise would contribute to lactate clearance. We also evaluated the effect of inspiratory muscle activation on blood flow response to the resting and e...
Introdução: Pacientes com insuficiência cardíaca (IC) apresentam redução de força e resistência dos músculos inspiratórios. Objetivo: Avaliar os efeitos do treinamento muscular inspiratório sobre a capacidade funcional, oscilação da ventilação, e sobre a qualidade de vida na IC. Pacientes e Métodos: Foram selecionados 33 pacientes com IC, que apresentavam fraqueza da musculatura inspiratória. Os pacientes foram...
The main objective of this study was to develop a polymeric drug delivery system for paclitaxel, intended to be intravenously administered, capable of improving the therapeutic index of the drug and devoid of the adverse effects of Cremophor® EL. To achieve this goal paclitaxel (Ptx)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Ptx-PLGA-Nps) were prepared by the interfacial deposition method. The...
Purpose: Simple methods for the large-scale manufacture of ligand-targeted liposomes will be needed if clinical trials are to proceed. We tested a recently developed technology for inserting peptide ligands into preformed Stealth liposomes. Antagonist G-targeted liposomes (PLG) were prepared and loaded with doxorubicin and their cellular association and cytotoxicity were evaluated using the human small cell lun...
Tumor accumulation and therapeutic activity of Stealth liposomes loaded with doxorubicin (DXR) were examined in Balb/c nude mice xenografts inoculated subcutaneously with the human small cell lung cancer (SCLC) cell line, H69. Mice were treated with non-targeted liposomes (SL) or liposomes targeted with antagonist G coupled to the liposome surface (SLG). SLG showed 30-44-fold higher binding to H69 cells harvest...
Financiadores do RCAAP | |||||||
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |