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Use of the Post-Insertion Technique to Insert Peptide Ligands into Pre-Formed S...
Moreira, João N.; Ishida, Tatsuhiro; Gaspar, Rogério; Allen, Theresa M.Purpose: Simple methods for the large-scale manufacture of ligand-targeted liposomes will be needed if clinical trials are to proceed. We tested a recently developed technology for inserting peptide ligands into preformed Stealth liposomes. Antagonist G-targeted liposomes (PLG) were prepared and loaded with doxorubicin and their cellular association and cytotoxicity were evaluated using the human small cell lun...
Targeting Stealth liposomes in a murine model of human small cell lung cancer
Moreira, João N.; Gaspar, Rogério; Allen, Theresa M.Tumor accumulation and therapeutic activity of Stealth liposomes loaded with doxorubicin (DXR) were examined in Balb/c nude mice xenografts inoculated subcutaneously with the human small cell lung cancer (SCLC) cell line, H69. Mice were treated with non-targeted liposomes (SL) or liposomes targeted with antagonist G coupled to the liposome surface (SLG). SLG showed 30-44-fold higher binding to H69 cells harvest...
A growth factor antagonist as a targeting agent for sterically stabilized lipos...
Moreira, João N.; Hansen, Christian B.; Gaspar, Rogério; Allen, Theresa M.The ability of a growth factor antagonist, [-Arg6,-Trp7,9-NmePhe8]-substance P(6-11), named antagonist G, to selectively target polyethylene glycol-grafted liposomes (known as sterically stabilized liposomes) to a human classical small cell lung cancer (SCLC) cell line, H69, was examined. Our results showed that radiolabeled antagonist G-targeted sterically stabilized liposomes (SLG) bound to H69 cells with hig...
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