Author(s):
Peixoto, Francisco 
; Lopes, M. ; Madeira, Vítor ; Vicente, Joaquim
Date: 2008
Persistent ID: http://hdl.handle.net/10316/7596
Origin: Estudo Geral - Universidade de Coimbra
Document details
Toxicity of MCPA on non-green potato tuber calli
Description
Abstract Growth of potato tuber calli cells (non-green) is inhibited by 4-chloro-2-methylphenoxyacetic acid (MCPA) as a consequence of perturbation of membrane integrity. MCPA also depresses ATP content with simultaneous increase of ADP and AMP, i.e., the energy charge is severely compromised. Cell redox state is also affected by MCPA, as a function of concentration. Up to 60 µM, MCPA stimulates glutathione reductase and glutathione transferase, whereas superoxide dismutase and catalase activities are not affected. However, 120 µM MCPA inhibits all these activities. Cell death challenged by MCPA is putatively related to disturbance of membrane integrity responsible for mitochondrial uncoupling with decrease of the energy charge and subsequent loss of ions and metabolites. http://dx.doi.org/10.1007/s11738-008-0207-x
Abstract Growth of potato tuber calli cells (non-green) is inhibited by 4-chloro-2-methylphenoxyacetic acid (MCPA) as a consequence of perturbation of membrane integrity. MCPA also depresses ATP content with simultaneous increase of ADP and AMP, i.e., the energy charge is severely compromised. Cell redox state is also affected by MCPA, as a function of concentration. Up to 60 µM, MCPA stimulates glutathione reductase and glutathione transferase, whereas superoxide dismutase and catalase activities are not affected. However, 120 µM MCPA inhibits all these activities. Cell death challenged by MCPA is putatively related to disturbance of membrane integrity responsible for mitochondrial uncoupling with decrease of the energy charge and subsequent loss of ions and metabolites. http://dx.doi.org/10.1007/s11738-008-0207-x
Document Type
Article
Language English
Language English
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