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Synthesis and studies of calcium channel blocking and antioxidant activities of...
Rucins, Martins; Kaldre, Dainis; Pajuste, Karlis; Fernandes, Maria A. S.; Vicente, Joaquim A. F.; Klimaviciusa, Linda; Jaschenko, ElinaThe novel 1,4-dihydropyridine derivatives containing the cationic pyridine moiety at the position 4, and the N-propargyl group as a substituent at position 1 of the 1,4-DHP cycle were designed, synthesised, and assessed in biological tests. Among all the novel compounds, the 4-(N-dodecyl) pyridinium group-containing compounds 11 (without the N-propargyl group) and 12 (with the N-propargyl group) demonstrated th...
Educação, retórica e filosofia a partir de Olivier Reboul : subsídios para uma ...
Vicente, Joaquim das NevesTese de doutoramento em Filosofia (Didáctica da Filosofia) apresentada à Fac. de Letras da Univ. de Coimbra
Ecophysiological tolerance of duckweeds exposed to copper
Kanoun-Boulé, Myriam; Vicente, Joaquim A. F.; Nabais, Cristina; Prasad, M. N. V.; Freitas, Helenahttp://www.sciencedirect.com/science/article/B6T4G-4TGXP9V-1/2/0652ab94eb95eab94ea56a82c424997b
INCLUSÃO DIGITAL: Mito ou realidade
CARLOS VICENTE JOAQUIMA partir do contexto histórico das três últimas decádas, verifica-se quais foram as transformações que ocorreram devido a introdução das tecnologias da comunicação e da informação- TICs - no Estado brasileiro. O estudo reflete sobre a temática da análise da política pública para a inclusão digital, com enfoque na emancipação tecnológica dos sujeitos atendidos por tal política. ; From the historical context o...
Comparative effects of the herbicides dicamba, 2,4-D and paraquat on non-green ...
Peixoto, Franciso P.; Gomes-Laranjo, José; Vicente, Joaquim A.; Madeira, Victor M.C.The effects of the herbicides 1,1'-dimethyl-4,4'-bipyridylium dichloride (paraquat), 3,6-dichloro-2-metoxybenzoic acid (dicamba) and 2,4-dichlorophenoxyacetic acid (2,4-D) on cell growth of non-green potato tuber calli are described. We attempted to relate the effects with toxicity, in particular the enzymes committed to the cellular antioxidant system. Cell cultures were exposed to the herbicides for a period ...
Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-121...
Fernandes, Maria A. S.; Pereira, Susana P. S.; Jurado, Amália S.; Custódio, José B. A.; Santos, Maria S.; Moreno, António J. M.; Duburs, GunarsThe 1,4-dihydropyridines OSI-1210, OSI-1211 (etaftoron), and OSI-3802 are compounds with similar chemical structure. They differ by the length of the alkoxyl chain in positions 3 and 5 of the dihydropyridine (DHP) ring and by their pharmacological action characteristics. However, as far as we know, a clear relationship between the effects of these compounds and the length of the alkoxyl chain in positions 3 and...
Toxicity of MCPA on non-green potato tuber calli
Peixoto, Francisco; Lopes, M.; Madeira, Vítor; Vicente, JoaquimAbstract Growth of potato tuber calli cells (non-green) is inhibited by 4-chloro-2-methylphenoxyacetic acid (MCPA) as a consequence of perturbation of membrane integrity. MCPA also depresses ATP content with simultaneous increase of ADP and AMP, i.e., the energy charge is severely compromised. Cell redox state is also affected by MCPA, as a function of concentration. Up to 60 µM, MCPA stimulates glutathione re...
Sildenafil citrate concentrations not affecting oxidative phosphorylation depre...
Fernandes, Maria; Marques, Ricardo; Vicente, Joaquim; Santos, Maria; Monteiro, Pedro; Moreno, António; Custódio, JoséAbstract Sildenafil citrate (Viagra) is a potent and specific inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), which exhibits cardioprotective action against ischemia/reperfusion injury in intact and isolated heart. The mechanism of its cardioprotective action is not completely understood, but some results suggested that sildenafil exerts cardioprotection through the...
Tetrandrine concentrations not affecting oxidative phosphorylation protect rat ...
Fernandes, Maria A. S.; Custódio, José B. A.; Santos, Maria S.; Moreno, António J. M.; Vicente, Joaquim A. F.The effects of tetrandrine (6,6', 7,12-tetramethoxy-2, 2'-dimethyl-berbaman) on the mitochondrial function were assessed on oxidative stress, mitochondrial permeability transition (MPT), and bioenergetics of rat liver mitochondria. At concentrations lower than 100 nmol/mg protein, tetrandrine decreased the hydrogen peroxide formation, the extent of lipid peroxidation, the susceptibility to Ca2+-induced opening ...
Teaching about citric acid cycle using plant mitochondrial preparations: Some a...
Vicente, Joaquim A. F.; Gomes-Santos, Carina S. S.; Sousa, Ana Paula M.; Madeira, Vítor M. C.Potato tubers and turnip roots were used to prepare purified mitochondria for laboratory practical work in the teaching of the citric acid cycle (TCA cycle). Plant mitochondria are particularly advantageous over the animal fractions to demonstrate the TCA cycle enzymatic steps, by using simple techniques to measure O2 consumption and transmembrane potential (ΔΨ). The several TCA cycle intermediates induce speci...
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