Development of liposomes with affinity to ischemic myocardium

• Author(s): Antunes, A. ; Botelho, M. F. ; Gomes, C. ; Lima, J. J. P. de ; Silva, M. L. ; Moreira, J. N. ; Simões, S. ; Gonçalves, L. ; Providência, L. A.
• Date: 2004
• Persistent ID: http://hdl.handle.net/10316/4784
• Origin: Estudo Geral - Universidade de Coimbra
• Document Type: Article
• Language: English

Description

Background: A major impediment to drug diagnosis and therapy of myocardial infarction is the limited access that drugs have to ischemic myocardium, dependent on regional myocardial blood flow. Investigators report that some liposomes concentrate in the experimental myocardial infarction, suggesting that they may be used to transport drugs to a region of ischemia. One of the most promising approaches for increasing liposome circulation time is coating them with polyethyleneglycol (PEG). http://www.sciencedirect.com/science/article/B6WKC-4D0XVDT-3B/1/e8e1e8ec0cf1dcf1546291ba169facff