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Fusão de imagens vídeo com imagens planares de medicina nuclear
Caramelo, F. J.; Faria, D.; Ferrreira, N. C.; Lima, J. J. P. deResumo da comunicação apresentado ao XII Congresso Nacional de Medicina Nuclear, 12-14 Novembro 2009, Mealhada
Development of liposomes with affinity to ischemic myocardium
Antunes, A.; Botelho, M. F.; Gomes, C.; Lima, J. J. P. de; Silva, M. L.; Moreira, J. N.; Simões, S.; Gonçalves, L.; Providência, L. A.Background: A major impediment to drug diagnosis and therapy of myocardial infarction is the limited access that drugs have to ischemic myocardium, dependent on regional myocardial blood flow. Investigators report that some liposomes concentrate in the experimental myocardial infarction, suggesting that they may be used to transport drugs to a region of ischemia. One of the most promising approaches for increas...
153Sm3+ and 111In3+ DTPA derivatives with high hepatic specificity: in vivo and...
Prata, M. I. M.; Santos, A. C.; Neves, M.; Geraldes, C. F. G. C.; Lima, J. J. P. deTwo DTPA derivatives, a mono-amide derivative containing an iodinated synthon, DTPA-IOPsp (L1) and the ligand DTPA(BOM)3 (BOM=benzyloxymethyl) (L2), radiolabelled with 153Sm3+ and 111In3+, were studied as potential hepatospecific gamma scintigraphic agents. In vivo studies with Wistar rats show that the main excretory pathway for all the chelates studied is the hepatobiliary system. The complexes of L2 show eve...
Characterization of 111In3+ complexes of DTPA amide derivatives: biodistributio...
Prata, M. I. M.; Santos, A. C.; Bligh, S. W. A.; Chowdhury, A. H. M. S.; Geraldes, C. F. G. C.; Lima, J. J. P. deA large series of structurally related diethylenetriaminepentaacetic acid amide derivatives with different structures and lipophilic properties were synthesized and radiolabeled with 111In3+. Two of the more hydrophobic compounds studied ([111In]L9 and [111In]L10) showed high affinity for human serum albumin (HSA). The biodistribution and clearance properties shown by all complexes upon injection in Wistar rats...
Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedi...
Prata, M. I. M.; Santos, A. C.; Geraldes, C. F. G. C.; Lima, J. J. P. deThe solution chemistry and structure of the complex of the triazamacrocyclic ligand NOTP (1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate)) with Ga3+ in D2O have been investigated by 1H, 71Ga and 31P NMR spectroscopy. These NMR results show the presence of a 1:1 Ga(NOTP)3- complex, with a highly symmetrical, pseudo-octahedral geometry, possibly with a C3 axis. The 1H spectrum shows that the triazamacroc...
Characterisation of 67Ga3+ complexes of triaza macrocyclic ligands: biodistribu...
Prata, M. I. M.; Santos, A. C.; Geraldes, C. F. G. C.; Lima, J. J. P. deThe 67Ga3+ complexes of three triazamacrocycles, 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), its phosphonate analog 1,4,7-triazacyclononane-N,N',N''-tris(methylenephosphonic) acid (NOTP), and the monoethyl ester of NOTP, 1,4,7-triazacyclononane-N,N',N''-tris (methylenephosphonatemonoethylester) (NOTPME) were studied for possible use as radiopharmaceuticals. Biodistribution studies and gamma imaging ...
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