Encontrados 16 documentos, a visualizar página 1 de 2
In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on...
Santos,A.O.; Pereira,J.P.; Pedroso de Lima,M.C.; Simões,S.; Moreira,J.N.Small cell lung cancer (SCLC) is an aggressive disease, representing 15% of all cases of lung cancer, has high metastatic potential and low prognosis that urgently demands the development of novel therapeutic approaches. One of the proposed approaches has been the down-regulation of BCL2, with poorly clarified and controversial therapeutic value regarding SCLC. The use of anti-BCL2 small interfering RNA (siRNA)...
Pustumeira: uma nova e boa opção forrageira para áreas de sequeiro.
ARAUJO, F. P. de; MOREIRA, J. N.; BRANDAO, W. N.2009
Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer
Santos, A.; Ribeiro, A. B. Sarmento; Lima, M. C. Pedroso de; Simões, S.; Moreira, J. N.When designing molecular targeted therapeutic strategies against cancer, it is important to correlate protein expression and cell viability. However, such goal can be difficult if performed in separate assays, especially when only a fraction of cells has been efficiently transfected. Therefore, the aim of the present study was to establish a flow cytometry procedure to assess simultaneously Bcl-2 protein level ...
Pustumeira: uma nova e boa opção forrageira para áreas de sequeiro.
ARAÚJO, F. P. de; MOREIRA, J. N.2006 ; 1 folder.
Development of liposomes with affinity to ischemic myocardium
Antunes, A.; Botelho, M. F.; Gomes, C.; Lima, J. J. P. de; Silva, M. L.; Moreira, J. N.; Simões, S.; Gonçalves, L.; Providência, L. A.Background: A major impediment to drug diagnosis and therapy of myocardial infarction is the limited access that drugs have to ischemic myocardium, dependent on regional myocardial blood flow. Investigators report that some liposomes concentrate in the experimental myocardial infarction, suggesting that they may be used to transport drugs to a region of ischemia. One of the most promising approaches for increas...
Antagonist G-mediated targeting and cytotoxicity of liposomal doxorubicin in NC...
Moreira, J. N.; Gaspar, R.The aim of the present study was to characterize the interactions of antagonist G (H-Arg-D-Trp-N(me)Phe-D-Trp-Leu-Met-NH 2)-targeted sterically stabilized liposomes with the human variant small cell lung cancer (SCLC) H82 cell line and to evaluate the antiproliferative activity of encapsulated doxorubicin against this cell line. Variant SCLC tumors are known to be more resistant to chemotherapy than classic SCL...
Antagonist G-mediated targeting and cytotoxicity of liposomal doxorubicin in NC...
Moreira,J.N.; Gaspar,R.The aim of the present study was to characterize the interactions of antagonist G (H-Arg-D-Trp-NmePhe-D-Trp-Leu-Met-NH 2)-targeted sterically stabilized liposomes with the human variant small cell lung cancer (SCLC) H82 cell line and to evaluate the antiproliferative activity of encapsulated doxorubicin against this cell line. Variant SCLC tumors are known to be more resistant to chemotherapy than classic SCLC ...
Feno de maniçoba uma alternativa de volumoso para ovinos no semi-árido brasilei...
ARAÚJO, G. G. L de; MOREIRA, J. N.; CAVALCANTI, J.; TURCO, S. H. N.2001
Cadeia produtiva de caprinos-ovinos no vale do rio Gavião: elementos para tomad...
CORREIA, R. C.; MOREIRA, J. N.; ARAUJO, J. L. P.; RAMOS, C. H. de S.Origem e efetivos das espécies caprinas-ovinas. Principais componentes: fornecedores de insumos anteriores a produção rural; sistemas de produção em uso: trajetória da atividade na região, sanidade e genética, assistência técnica, organização dos produtores, agregação de valor, alguns aspectos dos custos de produção e de geração de emprego, mercado e comercialização; Sistemas de intermediação e de transformação...
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