Detalhes do Documento

Nucleic acid oxidation in Alzheimer disease

Autor(es): Moreira, Paula I. cv logo 1 ; Nunomura, Akihiko cv logo 2 ; Nakamura, Masao cv logo 3 ; Takeda, Atsushi cv logo 4 ; Shenk, Justin C. cv logo 5 ; Aliev, Gjumrakch cv logo 6 ; Smith, Mark A. cv logo 7 ; Perry, George cv logo 8

Data: 2008

Identificador Persistente: http://hdl.handle.net/10316/4683

Origem: Estudo Geral - Universidade de Coimbra

Assunto(s): Alzheimer's disease; DNA oxidation; DNA repair; Oxidative stress; RNA damage; RNA repair; Free radicals


Descrição
Increasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure their longevity. In Alzheimer disease, however, an accumulation of nucleic acid oxidation is observed, indicating an increased level of oxidative stress and/or a decreased capacity to repair the nucleic acid damage. In this review, we present data supporting the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease. Furthermore, we outline the mechanisms of nucleic acid oxidation and repair. Finally, evidence showing the occurrence of nucleic acid oxidation in Alzheimer disease will be discussed. http://www.sciencedirect.com/science/article/B6T38-4RM7MWS-3/1/07d7e5640ecf31a878beade229f57950
Tipo de Documento Artigo
Idioma Inglês
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