Encontrados 2 documentos, a visualizar página 1 de 1

Ordenado por Data

Nucleic acid oxidation in Alzheimer disease

Moreira, Paula I.; Nunomura, Akihiko; Nakamura, Masao; Takeda, Atsushi; Shenk, Justin C.; Aliev, Gjumrakch; Smith, Mark A.; Perry, George

Increasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure...


Tau phosphorylation in Alzheimer's disease: pathogen or protector?

Lee, Hyoung-gon; Perry, George; Moreira, Paula I.; Garrett, Matthew R.; Liu, Quan; Zhu, Xiongwei; Takeda, Atsushi; Nunomura, Akihiko; Smith, Mark A.

During the past decade, hypotheses concerning the pathogenesis of most neurodegenerative diseases have been dominated by the notion that the aggregation of specific proteins and subsequent formation of cytoplasmic and extracellular lesions represent a harbinger of neuronal dysfunction and death. As such, in Alzheimer's disease, phosphorylated tau protein, the major component of neurofibrillary tangles, is consi...


2 Resultados

Texto Pesquisado

Refinar resultados

Autor











Data



Tipo de Documento


Recurso


Assunto












    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia