Encontrados 17 documentos, a visualizar página 1 de 2
Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioen...
Rato, Luis; Duarte, Ana I.; Tomás, Gonçalo D.; Santos, M. S.; Moreira, Paula I.; Socorro, Silvia; Cavaco, José E.; Alves, Marco G.; Oliveira, Pedro F.Pre-diabetes, a risk factor for type 2 diabetes development, leads to metabolic changes at testicular level. Peroxisome proliferator-activated receptor γ coactivator 1α(PGC-1α) and Sirtuin 3 (Sirt3) are pivotal inmitochondrial function. We hypothesized that pre-diabetes disrupts testicular PGC-1α/Sirt3 axis, compromising testicular mitochondrial function. Using a high-energy-diet induced pre-diabetic rat model,...
UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-ter...
Cardoso, Susana; Santos, M. S.; Moreno, A. J. M.; Moreira, Paula I.A growing body of evidence suggests that mitochondrial proton-leak functions as a regulator of reactive oxygen species production and its modulation may limit oxidative injury to tissues. The main purpose of this work was to characterize the proton-leak of brain cortical mitochondria from long-term hyperglycemic and insulininduced recurrent hypoglycemic rats through the modulation of the uncoupling protein 2 (U...
Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as The...
Cardoso, Susana; Santos, Renato; Correia, Sonia; Carvalho, Cristina; Zhu, Xiongwei; Lee, Hyoung-Gon; Casadesu, Gemma; Smith, Mark A.; Perry, GeorgeInsulin, besides its glucose lowering effects, is involved in the modulation of lifespan, aging and memory and learning processes. As the population ages, neurodegenerative disorders become epidemic and a connection between insulin signaling dysregulation, cognitive decline and dementia has been established. Mitochondria are intracellular organelles that despite playing a critical role in cellular metabolism ar...
Nucleic acid oxidation in Alzheimer disease
Moreira, Paula I.; Nunomura, Akihiko; Nakamura, Masao; Takeda, Atsushi; Shenk, Justin C.; Aliev, Gjumrakch; Smith, Mark A.; Perry, GeorgeIncreasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure...
Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced ...
Cardoso, Susana; Santos, Renato X.; Carvalho, Cristina; Correia, Sónia; Pereira, Gonçalo C.; Pereira, Susana S.; Oliveira, Paulo J.; Santos, Maria S.http://www.sciencedirect.com/science/article/B6T38-4T7087K-3/2/399a0c99d1e73842d49f885883fb79d7
Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
Moreira, Paula I.; Santos, Maria S.; Seiça, Raquel; Oliveira, Catarina R.It has been argued that in late-onset Alzheimer's disease a disturbance in the control of neuronal glucose metabolism consequent to impaired insulin signalling strongly resembles the pathophysiology of type 2 diabetes in non-neural tissue. The fact that mitochondria are the major generators and direct targets of reactive oxygen species led several investigators to foster the idea that oxidative stress and damag...
Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-...
Moreira, Paula I.; Custódio, José B.A.; Nunes, Elsa; Moreno, António; Seiça, Raquel; Oliveira, Catarina R.; Santos, Maria S.Given the tremendous importance of mitochondria to basic cellular functions as well as the critical role of mitochondrial impairment in a vast number of disorders, a compelling question is whether 17[beta]-estradiol (E2) modulates mitochondrial function. To answer this question we exposed isolated liver mitochondria to E2. Three groups of rat females were used: control, ovariectomized and ovariectomized treated...
Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-...
Moreira, Paula I.; Custódio, José B.A.; Nunes, Elsa; Moreno, António; Seiça, Raquel; Oliveira, Catarina R.; Santos, Maria S.Given the tremendous importance of mitochondria to basic cellular functions as well as the critical role of mitochondrial impairment in a vast number of disorders, a compelling question is whether 17[beta]-estradiol (E2) modulates mitochondrial function. To answer this question we exposed isolated liver mitochondria to E2. Three groups of rat females were used: control, ovariectomized and ovariectomized treated...
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stre...
Moreira, Paula I.; Harris, Peggy L. R.; Zhu, Xiongwei; Santos, Maria S.; Oliveira, Catarina R.; Smith, Mark A.; Perry, GeorgeIn this study, we evaluated the effect of lipoic acid (LA) and N-acetyl cysteine (NAC) on oxidative [4-hydroxy-2-nonenal, N(epsilon)-(carboxymethyl)lysine and heme oxygenase-1] and apoptotic (caspase 9 and Bax) markers in fibroblasts from patients with Alzheimer disease (AD) and age-matched and young controls. AD fibroblasts showed the highest levels of oxidative stress, and the antioxidants, lipoic acid (1 mM)...
Tamoxifen and estradiol interact with the flavin mononucleotide site of complex...
Moreira, Paula I.; Custódio, José; Moreno, António; Oliveira, Catarina R.; Santos, Maria S.This study evaluated the action of tamoxifen and estradiol on the function of isolated liver mitochondria. We observed that although tamoxifen and estradiol per se did not affect mitochondrial complexes II, III, or IV, complex I is affected, this effect being more drastic (except for state 4 of respiration) when mitochondria were coincubated with both drugs. Furthermore, using two respiratory chain inhibitors, ...
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