Detalhes do Documento

GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is ...

Autor(es): Donato, Roberta cv logo 1 ; Rodrigues, Ricardo J. cv logo 2 ; Takahashi, Michiko cv logo 3 ; Tsai, Ming Chi cv logo 4 ; Soto, David cv logo 5 ; Miyagi, Kana cv logo 6 ; Villafuertes, Rosa Gomez cv logo 7 ; Cunha, Rodrigo A. cv logo 8 ; Edwards, Frances A. cv logo 9

Data: 2008

Identificador Persistente: http://hdl.handle.net/10316/4679

Origem: Estudo Geral - Universidade de Coimbra

Assunto(s): Purkinje cell; Cerebellar cortex; Purinergic; GABA release; Calcium influx; Calcium stores; Synaptic transmission; Presynaptic receptors


Descrição
In many brain regions, Ca2+ influx through presynaptic P2X receptors influences GABA release from interneurones. In patch-clamp recordings of Purkinje cells (PCs) in rat cerebellar slices, broad spectrum P2 receptor antagonists, PPADS (30 [mu]M) or suramin (12 [mu]M), result in a decreased amplitude and increased failure rate of minimal evoked GABAergic synaptic currents from basket cells. The effect is mimicked by desensitizing P2X1/3-containing receptors with [alpha],[beta]-methylene ATP. This suggests presynaptic facilitation of GABA release via P2XR-mediated Ca2+ influx activated by endogenously released ATP. In contrast, activation of P2Y4 receptors (using UTP, 30 [mu]M, but not P2Y1 or P2Y6 receptor ligands) results in inhibition of GABA release. Immunological studies reveal the presence of most known P2Rs in >=20% of GABAergic terminals in the cerebellum. P2X3 receptors and P2Y4 receptors occur in approximately 60% and 50% of GABAergic synaptosomes respectively and are localized presynaptically. Previous studies report that PC output is also influenced by postsynaptic purinergic receptors located on both PCs and interneurones. http://www.sciencedirect.com/science/article/B6WCC-4SGTM4N-1/1/18be0bd4d3f723826c492461dcb46423
Tipo de Documento Artigo
Idioma Inglês
delicious logo  facebook logo  linkedin logo  twitter logo 
degois logo
mendeley logo

Documentos Relacionados



    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia