Encontrados 28 documentos, a visualizar página 1 de 3
Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopami...
Salamone, Alessia; Zappettini, Stefania; Grilli, Massimo; Guendalina, Paula; Tomé, Angelo R.; Chen, Jiayang; Pittaluga, Anna; Cunha, Rodrigo A.The presynaptic control of dopamine release in the nucleus accumbens (NAc) by glutamate and acetylcholine has a profound impact on reward signaling. Here we provide immunocytochemical and neurochemical evidence supporting the co-localization and functional interaction between nicotinic acetylcholine receptors (nAChRs) and N-methyl-D-aspartic acid (NMDA) receptors in dopaminergic terminals of the NAc. Most NAc d...
Caffeine, adenosine receptors, and synaptic plasticity
Costenla, Ana Rita; Cunha, Rodrigo A.; Mendonça, Alexandre deCopyright ©2012 IOS Press All rights reserved. ; Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those that did used very high concentrations of caffeine, whereas the brain concentrations attained by regular coffee consumption in humans should be in the low micromolar range, where caffeine exerts pharmacological actions mainly by antagonizing adenosine receptors. Accordin...
N-acyldopamines control striatal input terminals via novel ligand-gated cation ...
Ferreira, Samira G.; Lomaglio, Tonia; Avelino, Antonio; Cruz, Francisco; Oliveira, Catarina R.; Cunha, Rodrigo A.; Köfalvi, Attilahttp://www.sciencedirect.com/science/article/B6T0C-4V3HHM3-1/2/22d594101b6927eca47e1b39b53ffcee
GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is ...
Donato, Roberta; Rodrigues, Ricardo J.; Takahashi, Michiko; Tsai, Ming Chi; Soto, David; Miyagi, Kana; Villafuertes, Rosa Gomez; Cunha, Rodrigo A.In many brain regions, Ca2+ influx through presynaptic P2X receptors influences GABA release from interneurones. In patch-clamp recordings of Purkinje cells (PCs) in rat cerebellar slices, broad spectrum P2 receptor antagonists, PPADS (30 [mu]M) or suramin (12 [mu]M), result in a decreased amplitude and increased failure rate of minimal evoked GABAergic synaptic currents from basket cells. The effect is mimicke...
Modification upon aging of the density of presynaptic modulation systems in the...
Canas, Paula M.; Duarte, João M. N.; Rodrigues, Ricardo J.; Köfalvi, Attila; Cunha, Rodrigo A.Different presynaptic neuromodulation systems have been explored as possible targets to manage neurodegenerative diseases. However, most studies used young adult animals whereas neurodegenerative diseases are prevalent in the elderly. Thus, we now explored by Western blot analysis how the density of different presynaptic markers and receptors changes with aging in rat hippocampal synaptosomes (purified nerve te...
Different cellular sources and different roles of adenosine: A1 receptor-mediat...
Cunha, Rodrigo A.Adenosine is a prototypical neuromodulator, which mainly controls excitatory transmission through the activation of widespread inhibitory A1 receptors and synaptically located A2A receptors. It was long thought that the predominant A1 receptor-meditated modulation by endogenous adenosine was a homeostatic process intrinsic to the synapse. New studies indicate that endogenous extracellular adenosine is originate...
Modification of adenosine modulation of acetylcholine release in the hippocampu...
Rodrigues, Ricardo J.; Canas, Paula M.; Lopes, Luísa V.; Oliveira, Catarina R.; Cunha, Rodrigo A.Adenosine is a neuromodulator acting through inhibitory A1 receptors (A1Rs) and facilitatory A2ARs. Since A2AR antagonists attenuate memory deficits in aged animals and memory deficits might involve a decreased cholinergic function, we investigated how aging affects the density and function of adenosine receptors in rat hippocampal cholinergic terminals. In young adult (2 months) rats, 64 and 36% of cholinergic...
Adenosine A2A receptor antagonists exert motor and neuroprotective effects by d...
Yu, Liqun; Shen, Hai-Ying; Coelho, Joana E.; Araújo, Inês M.; Huang, Qing-Yuan; Day, Yuan-Ji; Rebola, Nelson; Canas, Paula M.; Rapp, Erica KirstenTo investigate whether the motor and neuroprotective effects of adenosine A2A receptor (A2AR) antagonists are mediated by distinct cell types in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease.We used the forebrain A2AR knock-out mice coupled with flow cytometric analyses and intracerebroventricular injection to determine the contribution of A2ARs in forebrain neurons and gl...
Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders
Cunha, Rodrigo A.; Ferré, Sergi; Vaugeois, Jean-Marie; Chen, Jiang-FanThe interest on targeting adenosine A(2A) receptors in the realm of psychiatric diseases first arose based on their tight physical and functional interaction with dopamine D(2) receptors. However, the role of central A(2A) receptors is now viewed as much broader than just controlling D(2) receptor function. Thus, there is currently a major interest in the ability of A(2A) receptors to control synaptic plasticit...
Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotoc...
Duarte, João M. N.; Nogueira, Célia; Mackie, Ken; Oliveira, Catarina R.; Cunha, Rodrigo A.; Köfalvi, AttilaIn the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB1R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, ...
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