Author(s):
Duarte, Ana Rita C. 
; Coimbra, Patrícia ; Sousa, Hermínio C. de ; Duarte, Catarina M. M.
Date: 2004
Persistent ID: http://hdl.handle.net/10316/10384
Origin: Estudo Geral - Universidade de Coimbra
Document details
Solubility of Flurbiprofen in Supercritical Carbon Dioxide
Description
Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model. http://dx.doi.org/10.1021/je034099b
Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model. http://dx.doi.org/10.1021/je034099b
Document Type
Article
Language English
Language English
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