Effect of selenium supplementation on some blood biochemical parameters in male...

• Author(s): Crespo, A.M.V. ; Lança, M.J. ; Vasconcelos, S. ; Andrade, V. ; Rodrigues, H. ; Santos, M.C.
• Date: 1995
• Persistent ID: http://hdl.handle.net/10174/4036
• Origin: Repositório Científico da Universidade de Évora
• Subject(s): selenium; male rats
• Document Type: Lecture
• Language: English

Description

The long-term effect of selenium supplementation on blood glutathione peroxidase (GSH-Px) activity and plasma TBARS’ production (as an index of peroxidation) was evaluated in 15-mo-old male rats fed a diet supplemented with 0.25 or 0.50 ppm selenium, for 12 mo. A group of nonsupplemented age-matched rats was the control. In addition, triglycerides, phospholipids, total and free cholesterol, HDL-cholesterol, and HDL-phospholipid levels were measured in plasma. Plasma testosterone levels were also determined in order to control the aging process in these animals. The GSH-Px activity and the peroxidation level were unchanged in all the groups. However, concerning the lipid parameters, a decrease in triglycerides concentration was observed in both treated groups (p<0.05). Therefore, in these experimental conditions, despite no observed changes in parameters related to lipid peroxidation, selenium seems to be involved with triglycerides metabolism, eventually improving the triglycerides status of aged animals.