1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibito...

• Author(s): Peixoto, Daniela ; Calhelha, Ricardo C. ; Soares, Pedro ; Abreu, Rui M.V. ; Froufe, Hugo J.C. ; Ferreira, Isabel C.F.R. ; Costa, Raquel ; Soares, Raquel ; Queiroz, Maria João R.P.
• Date: 2012
• Persistent ID: http://hdl.handle.net/10198/9474
• Origin: Biblioteca Digital do IPB
• Document Type: Conference Object
• Language: English

Description

A number of thienopyrimidines derivatives have shown potent VEGFR2 (Vascular Endothelium Growth Factor Receptor2) tyrosine kinase inhibition activity.[ll VEGF is a sun·ogate marker of angiogenesis that activates VEGFR2 in endothelial cells. Here we present the synthesis of new 1-aryl-3-[ 4-(thieno[3,2-d]pyrimidin-4- yloxy)phenyl]ureas from the aminodi(hetero)arylether 1, also prepared by us, which was reacted with arylisocyanates to give the corresponding 1,3-diarylureas 2a-c.