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Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: ...

The antioxidant activity of the aminodi(hetero)arylamines, prepared by C-N coupling of the methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with bromonitrobenzenes and further reduction of the obtained nitro compounds, was evaluated by chemical, biochemical and electrochemical assays. The aminodi(hetero) arylamine with the amino group ortho to the NH and a methoxy group in para, was the most efficient in radic...

BoImAr: Borylation(Catalytic)-Imination-Arylation(Catalytic) - A New Synthetic ...

Although dramatic progress has been made in understanding the pathogenesis of neurodegenerative conditions of the aged population such as Alzheimer's disease, Parkinson's disease and Fronto-Temporal dementia, to date most of these diseases are incurable. Because of the aging population, these disorders pose a serious challenge to the health care system. Loss of synapses is probably the common neuropathological ...

Avaliação do status de vitamina D na artrite idiopática juvenil

A insuficiência de 25-hidroxivitamina D tem sido associada a várias patologias crónicas imunomediadas, no entanto, existem poucos dados na literatura relativamente à sua associação à artrite idiopática juvenil (AIJ). O objetivo deste estudo era avaliar os níveis de vitamina D em crianças e adultos com AIJ e sua eventual relação com a gravidade da doença. A determinação sérica de vitamina D foi efetuada em 39 do...

New 1,3-diarylureas linked by C-C Suzuki coupling to the methyl 3-aminothieno[3...

New six fluorescent 1,3-diarylureas linked by C-C Suzuki coupling to the 6-position of the methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate moiety were prepared by reaction of the amino groups on the ortho or meta positions relative to the C-C bond of the Suzuki coupling products, with different para-substituted arylisocyanates (H, OMe, CN), in high to excellent yields. The fluorescence properties of the 1,3-d...

Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2...

Synthesis of thienopyridine derivatives as potential antitumorals and/or antian...

Thieno[3,2-b]pyridine arylethers : synthesis and growth inhibitory activity on ...

Synthesis, docking, enzymatic and cellular assays of thieno[3,2-b]pyridine-thio...

Synthesis, growth inhibitory activity on human tumor cell lines and evaluation ...

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine ki...

The Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) is a tyrosine kinase receptor involved in the growth and differentiation of endothelial cells that is implicated in tumor-associated angiogenesis. In this study novel 1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas were synthesized and evaluated for the VEGFR-2 tyrosine kinase inhibition. Three of these compounds showed good VEGFR-2 inhibition...